Jamshidi-Naeini Yasaman, Vorland Colby J, Kapoor Pranav, Ortyl Bailey, Mineo Jocelyn, Still Luke, Sorsor Korlu, Rodney Shelby, Tooze Xander, Flickinger Brent, Henschel Beate, Dickinson Stephanie L, Allison David B
Department of Epidemiology and Biostatistics, Indiana University School of Public Health-Bloomington, IN, USA.
Department of Applied Health Science, Indiana University School of Public Health-Bloomington, IN, USA.
medRxiv. 2024 Dec 2:2024.12.01.24318272. doi: 10.1101/2024.12.01.24318272.
The credibility of nutritional research is dependent on the rigor with which studies are conducted and the ability for independent assessment to be performed. Despite the importance of these, more work is needed in the field of nutrition to buttress the trustworthiness of nutrition research.
To develop and apply a process for evaluating the rigor, reproducibility, and verifiability of nutritional research, using the relationship between potato consumption and Colorectal cancer (CRC) as a case study.
We updated existing systematic reviews to include studies on potatoes and CRC, assessing their design, execution, and reporting quality. We attempted to reproduce and verify the results of included studies by requesting raw data from authors and following statistical methods as described in the publications. Rigor was evaluated using four different tools: ROBINS-E, STROBE-Nut, Newcastle-Ottawa scale, and additional criteria related to transparency.
Eighteen studies were included, none of which publicly share data. We managed to access data for only two studies, successfully reproducing and verifying the results for one. The majority of studies exhibited a high risk of bias, with significant limitations in reporting quality and methodological rigor.
Research on the relationship between potato consumption and CRC risk is insufficiently reproducible and verifiable, undermining the trustworthiness of its findings. This study highlights the need for improving transparency, data sharing, and methodological rigor in nutritional research. Our approach provides a model for assessing the credibility of research in other areas of nutrition.
营养研究的可信度取决于研究开展的严谨程度以及进行独立评估的能力。尽管这些很重要，但在营养领域仍需开展更多工作来增强营养研究的可信度。
以土豆消费与结直肠癌（CRC）之间的关系为例，开发并应用一种评估营养研究的严谨性、可重复性和可验证性的流程。
我们更新了现有的系统评价，纳入关于土豆与结直肠癌的研究，评估其设计、实施和报告质量。我们通过向作者索要原始数据并遵循出版物中描述的统计方法，试图重现和验证纳入研究的结果。使用四种不同工具评估严谨性：ROBINS-E、STROBE-Nut、纽卡斯尔-渥太华量表以及与透明度相关的其他标准。
纳入了18项研究，其中没有一项公开共享数据。我们仅设法获取了两项研究的数据，成功重现并验证了其中一项的结果。大多数研究存在较高的偏倚风险，在报告质量和方法严谨性方面存在重大局限性。
关于土豆消费与结直肠癌风险之间关系的研究可重复性和可验证性不足，削弱了其研究结果的可信度。本研究强调了在营养研究中提高透明度、数据共享和方法严谨性的必要性。我们的方法为评估营养其他领域研究的可信度提供了一个模型。
