Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Adv Exp Med Biol. 2021;1308:55-89. doi: 10.1007/978-3-030-64872-5_6.
Malignant conditions of the gastrointestinal tract and accessory organs of digestion, including the oral cavity, esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus, are referred to as gastrointestinal cancers. Curcumin is a natural compound derived from turmeric with a wide range of biological activities. Several in vitro and in vivo studies have investigated the effects of curcumin on gastrointestinal cancers. In the current review, we aimed to provide an updated summary on the recent findings regarding the beneficial effects of curcumin on different gastrointestinal cancers in the recent decade. For this purpose, ScienceDirect," "Google Scholar," "PubMed," "ISI Web of Knowledge," and "Wiley Online Library" databases were searched using "curcumin", "cancer", and "gastrointestinal organs" as keywords. In vitro studies performed on different gastrointestinal cancerous cell lines have shown that curcumin can inhibit cell growth through cycle arrest at the G2/M and G1 phases, as well as stimulated apoptosis and autophagy by interacting with multiple molecular targets. In vivo studies performed in various animal models have confirmed mainly the chemopreventive effects of curcumin. Several nano-formulations have been proposed to improve the bioavailability of curcumin and increase its absorption. Moreover, curcumin has been used in combinations with many anti-tumor drugs to increase their anticarcinogenic properties. Taken together, curcumin falls within the category of plant-derived substances capable of preventing or treating gastrointestinal cancers. Further studies, particularly clinical trials, on the efficacy and safety of curcumin are suggested in this regard.
胃肠道和消化附属器官的恶性疾病，包括口腔、食管、胃、胆道系统、胰腺、小肠、大肠、直肠和肛门，被称为胃肠道癌症。姜黄素是一种从姜黄中提取的天然化合物，具有广泛的生物活性。一些体外和体内研究已经研究了姜黄素对胃肠道癌症的影响。在本次综述中，我们旨在提供一个关于近十年来姜黄素对不同胃肠道癌症的有益作用的最新研究结果的综合概述。为此，我们使用“curcumin”、“cancer”和“gastrointestinal organs”作为关键字，在 ScienceDirect、“Google Scholar”、“PubMed”、“ISI Web of Knowledge”和“Wiley Online Library”数据库中进行了搜索。在不同胃肠道癌细胞系上进行的体外研究表明，姜黄素可以通过在 G2/M 和 G1 期使细胞周期停滞，以及通过与多个分子靶点相互作用刺激细胞凋亡和自噬来抑制细胞生长。在各种动物模型中进行的体内研究主要证实了姜黄素的化学预防作用。已经提出了几种纳米制剂来提高姜黄素的生物利用度并增加其吸收。此外，姜黄素已与许多抗肿瘤药物联合使用，以增加其抗癌特性。总的来说，姜黄素属于能够预防或治疗胃肠道癌症的植物源性物质。在这方面，建议进一步研究，特别是关于姜黄素的疗效和安全性的临床试验。
