Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Internal Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Biomed Pharmacother. 2021 Sep;141:111849. doi: 10.1016/j.biopha.2021.111849. Epub 2021 Jun 30.
Curcumin is a bioactive ingredient found in the Rhizomes of Curcuma longa. Curcumin is well known for its chemopreventive and anti-cancer properties. Recent findings have demonstrated several pharmacological and biological impacts of curcumin, related to the control and the management of gastrointestinal cancers. Mechanistically, curcumin exerts its biological impacts via antioxidant and anti-inflammatory effects through the interaction with various transcription factors and signaling molecules. Moreover, epigenetic modulators such as microRNAs (miRNAs) have been revealed as novel targets of curcumin. Curcumin was discovered to regulate the expression of numerous pathogenic miRNAs in gastric, colorectal, esophageal and liver cancers. The present systematic review was performed to identify miRNAs that are modulated by curcumin in gastrointestinal cancers.
姜黄素是姜黄根茎中的一种生物活性成分。姜黄素以其化学预防和抗癌特性而闻名。最近的研究结果表明，姜黄素具有多种与控制和管理胃肠道癌症相关的药理学和生物学作用。从机制上讲，姜黄素通过与各种转录因子和信号分子相互作用发挥其抗氧化和抗炎作用，从而产生生物学影响。此外，诸如 microRNAs (miRNAs) 等表观遗传调节剂已被揭示为姜黄素的新型靶标。研究发现，姜黄素有调节胃、结直肠、食管和肝癌中许多致病 miRNA 的表达。本系统评价旨在确定姜黄素在胃肠道癌症中调节的 miRNA。
