Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Life Sci. 2021 Jul 15;277:119488. doi: 10.1016/j.lfs.2021.119488. Epub 2021 Apr 19.
Glioblastoma is recognized as one of the leading causes of death worldwide. Although there have been considerable advancements in understanding the causative molecular mechanisms of this malignancy, effective therapeutic strategies are still in limited use. It has been revealed that non-coding RNAs (ncRNAs) play critical roles in glioblastoma development, while interactions between the regulatory molecules such as long ncRNAs (lncRNAs), microRNAs (miRNAs), transcribed pseudogenes, and circular RNAs (circRNAs) remain to be fully deciphered. Over the recent years, researchers have discovered a new category of RNA molecules called competing endogenous RNA (ceRNA). This kind of RNA can contribute to molecular interactions in the form of ceRNA networks (ceRNETs). Multiple lines of evidence have demonstrated that dysregulation of various ceRNA networks is involved in glioblastoma development. Therefore, gaining insights into these dysregulations might offer potential for the early diagnosis of glioblastoma patients and identification of efficient therapeutic targets. In this review, we provide an overview of recent discoveries on ceRNA networks and the involvement of dysregulated networks in posing limitations to temozolomide therapy. We also describe signaling pathways relevant to the progression of glioblastoma.
胶质母细胞瘤被认为是全球主要的死亡原因之一。尽管在理解这种恶性肿瘤的致病分子机制方面已经取得了相当大的进展，但有效的治疗策略仍在有限的应用中。已经发现非编码 RNA（ncRNAs）在胶质母细胞瘤的发展中起着关键作用，而长链非编码 RNA（lncRNAs）、微小 RNA（miRNAs）、转录假基因和环状 RNA（circRNAs）等调节分子之间的相互作用仍有待完全阐明。近年来，研究人员发现了一类称为竞争内源性 RNA（ceRNA）的新型 RNA 分子。这种 RNA 可以以 ceRNA 网络（ceRNETs）的形式参与分子相互作用。多项证据表明，各种 ceRNA 网络的失调参与了胶质母细胞瘤的发展。因此，深入了解这些失调可能为胶质母细胞瘤患者的早期诊断和有效治疗靶点的识别提供可能。在这篇综述中，我们概述了 ceRNA 网络的最新发现以及失调网络在限制替莫唑胺治疗中的作用。我们还描述了与胶质母细胞瘤进展相关的信号通路。
