心脏移植后与 COVID-19 相关的心肌炎
COVID-19-related myocarditis post-heart transplantation.
作者信息
Roest Stefan, Brugts Jasper J, van Kampen Jeroen J A, von der Thüsen Jan H, Constantinescu Alina A, Caliskan Kadir, Hirsch Alexander, Manintveld Olivier C
机构信息
Department of Cardiology, Thorax Center, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Viroscience, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
出版信息
Int J Infect Dis. 2021 Jun;107:34-36. doi: 10.1016/j.ijid.2021.04.013. Epub 2021 Apr 20.
This report describes the first heart transplantation recipient with acute biventricular heart failure symptoms caused by a post-myocarditis state, late after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. No other viral pathogens could be detected. Computed tomography angiography did not show cardiac allograft vasculopathy, and myocardial biopsy demonstrated no clinically relevant rejection. Subsequent cardiovascular magnetic resonance imaging revealed extensive epicardial delayed enhancement without myocardial edema. Heart failure medication was initiated and an implantable cardioverter defibrillator was implanted (due to non-sustained ventricular tachycardias), leading to a partial recovery of the ejection fraction. Further studies are needed to investigate the number of heart transplant recipients with myocardial damage after a SARS-CoV-2 infection.
本报告描述了首例在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染后晚期出现由心肌炎后状态引起的急性双心室心力衰竭症状的心脏移植受者。未检测到其他病毒病原体。计算机断层扫描血管造影未显示心脏移植血管病变，心肌活检未发现临床相关排斥反应。随后的心血管磁共振成像显示广泛的心外膜延迟强化但无心肌水肿。开始使用心力衰竭药物治疗，并植入了植入式心脏复律除颤器（由于非持续性室性心动过速），导致射血分数部分恢复。需要进一步研究以调查SARS-CoV-2感染后出现心肌损伤的心脏移植受者数量。
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