患者和其家庭接触者的粪便宏基因组分析。
Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners.
机构信息
Division of Infectious Diseases, National University Hospital, National University Health System, Singapore 119228, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
National Centre for Infectious Diseases, Singapore 308442, Singapore.
出版信息
Int J Infect Dis. 2021 Jun;107:1-4. doi: 10.1016/j.ijid.2021.04.012. Epub 2021 Apr 16.
OBJECTIVES
Hypermucoviscous Klebsiella pneumoniae is an emerging cause of community-acquired liver abscess. The aim of this study was to investigate whether hypermucoviscous strains could be shared among households.
METHODS
The clinical K. pneumoniae isolates from a cohort of 24 patients with Klebsiella liver abscess were genotyped, and the stool metagenomes of the index patients and their cohabiting domestic partners were analyzed.
RESULTS
K. pneumoniae was identified in 33% of index patient stools, and one index patient's clinical isolate was identified in their domestic partner's stool.
CONCLUSIONS
This could represent a transmission event or could represent exposure to a common environmental source.
目的
高黏液型肺炎克雷伯菌是社区获得性肝脓肿的一个新出现的病因。本研究旨在探讨高黏液型菌株是否可在家庭中传播。
方法
对 24 例肺炎克雷伯菌肝脓肿患者的临床肺炎克雷伯菌分离株进行基因分型，并分析了指数患者及其同居的家庭伴侣的粪便宏基因组。
结果
33%的指数患者粪便中检出肺炎克雷伯菌，1 例指数患者的临床分离株在其家庭伴侣的粪便中检出。
结论
这可能代表一次传播事件，也可能代表暴露于共同的环境来源。
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