Savino W, Bartoccioni E, Homo-Delarche F, Gagnerault M C, Itoh T, Dardenne M
INSERM U25, Hôpital Necker, Paris, France.
J Steroid Biochem. 1988;30(1-6):479-84. doi: 10.1016/0022-4731(88)90148-3.
We investigated the in vitro effects (kinetics and dose-response) of adrenal and sexual steroid hormones on the secretion of thymulin, a thymic hormone, by human thymic epithelial cells in primary cultures as well as in a rat epithelial cell line. We demonstrated that all steroids tested, in a range of physiological doses, stimulated thymulin production to various extents. Progesterone and estradiol, however, were revealed to be the most efficient. Specific steroid antagonists abrogated the steroid-induced stimulation of thymulin production. These findings confirm our previous in vivo results and demonstrate that steroid hormones can act directly on thymic epithelial cells to modulate their endocrine production.
我们研究了肾上腺和性甾体激素对原代培养的人胸腺上皮细胞以及大鼠上皮细胞系中胸腺激素胸腺素分泌的体外作用（动力学和剂量反应）。我们证明，在所测试的一系列生理剂量下，所有甾体激素均能不同程度地刺激胸腺素的产生。然而，已发现孕酮和雌二醇最为有效。特异性甾体拮抗剂消除了甾体诱导的胸腺素产生刺激。这些发现证实了我们之前的体内研究结果，并表明甾体激素可直接作用于胸腺上皮细胞以调节其内分泌产物。
