Yee E S, Ullyot D J
Department of Surgery, University of California, San Francisco.
J Thorac Cardiovasc Surg. 1988 Jul;96(1):133-40.
From 1981 to 1986, 12 patients were operated on for right-sided endocarditis after the failure of initial medical treatment (five staphylococcal, three streptococcal, two fungal, one gram-negative, and one mixed organism). The sources of infection were intravenous drugs in six patients, central catheters in two, and malformations in four. Preoperatively, 10 of 12 (83%) of these patients were in class III or IV. Reparative or reconstructive approaches, including valvuloplasty, were attempted for all these right-sided endocarditis lesions and were hemodynamically effective in 10 of 12 (83%) patients. The low right-sided intracardiac pressures and the three-leaflet configuration (one pulmonary and nine tricuspid valves) have lent themselves to this approach. Extensive annular invasion and multileaflet infections were technical limitations in the remaining patients. The overall outcome was favorable during the mean follow-up period of 25 months (hospital mortality 1/12, 8.3%; late death 1/11, 9%). Reparative or reconstructive approaches for right-sided infective endocarditis should be considered and can be successfully achieved. Their advantages include (1) improved hemodynamics, (2) low recurrence, and (3) favorable long-term results without staged or simultaneous prosthetic valve replacement.
1981年至1986年期间,12例患者在初始药物治疗失败后接受了右侧心内膜炎手术(5例为葡萄球菌感染,3例为链球菌感染,2例为真菌感染,1例为革兰阴性菌感染,1例为混合菌感染)。感染源为6例患者的静脉药物滥用、2例患者的中心静脉导管以及4例患者的心脏畸形。术前,这些患者中有10例(83%)属于心功能Ⅲ级或Ⅳ级。对所有这些右侧心内膜炎病变均尝试了修复或重建方法,包括瓣膜成形术,12例患者中有10例(83%)血流动力学效果良好。右侧心腔内压力较低以及三叶瓣结构(1个肺动脉瓣和9个三尖瓣)有利于采用这种方法。广泛的瓣环侵犯和多叶瓣感染是其余患者的技术限制因素。在平均25个月的随访期内,总体结果良好(住院死亡率1/12,8.3%;晚期死亡1/11,9%)。对于右侧感染性心内膜炎,应考虑采用修复或重建方法,并且可以成功实现。其优点包括:(1)改善血流动力学;(2)低复发率;(3)无需分期或同期置换人工瓣膜即可获得良好的长期效果。