Mazzini Cinzia, Vicini Giulio, Nicolosi Cristina, Pieretti Giulia, Rizzo Stanislao
Unit of Ocular Oncology, Neuromuscular and Sense Organs Department, Careggi University Hospital, Florence, Italy.
Eye Clinic, Neuromuscular and Sense Organs Department, Careggi University Hospital, Florence, Italy.
Eur J Ophthalmol. 2021 Apr 16:11206721211010616. doi: 10.1177/11206721211010616.
To describe the findings of four patients (four eyes) with optic disc melanocytoma (ODM), using multimodal imaging.
Retrospective case series.
On ocular ultrasonography ODMs appeared as hyperechogenic lesions with moderate-to-high internal reflectivity. On blue-light fundus autofluorescence, ODMs showed total hypoautofluorescence, while, on infrared reflectance images appeared as bright and well-marginated lesions. MultiColor composite images showed reddish-brown lesions with well-defined margins. Swept-source optical coherence tomography revealed elevated lesions covering the optic disc with an irregular hyperreflective surface, dishomogeneous internal structure with hyperreflective dots, and posterior shadowing. In all cases optical coherence tomography angiography detected intratumoral blood vessels which were not detectable with fluorescein angiography.
Multimodal imaging in ODM might be useful both at presentation, increasing the diagnostic accuracy, and at follow-up, providing helpful details, that can help to rule out the possibility of malignant transformation and other ocular complications.
使用多模态成像描述4例（4只眼）视盘黑色素细胞瘤（ODM）患者的检查结果。
回顾性病例系列研究。
眼部超声检查显示，ODM表现为内部反射率中等至高的高回声病变。在蓝光眼底自发荧光检查中，ODM呈现完全低自发荧光，而在红外反射图像上则表现为边界清晰的明亮病变。多色合成图像显示边界清晰的红棕色病变。扫频光学相干断层扫描显示病变隆起，覆盖视盘，表面不规则高反射，内部结构不均匀，有高反射点，且后方有阴影。在所有病例中，光学相干断层扫描血管造影均检测到肿瘤内血管，而荧光素血管造影未检测到。
ODM的多模态成像在初诊时可能有助于提高诊断准确性，在随访时可提供有用细节，有助于排除恶性转化和其他眼部并发症的可能性。
