[Effects of chronic administration of dimebon on behavior and memory of SAMP 10 mice].

SAMP 10 mice with genetically determined senescence (senescence-accelerated mouse prone 10) aged 16 months demonstrated (in comparison to 3-months old animals of the same strain) the following traits typical of old animal: behavior and memory deficiency, exploratory behavior impairment, and elevated level of anxiety. Dimebon administered for a long period of time with drinking water (1.5 mg/kg over 5 months) produced a positive action upon behavior and memory of 16-months-old SAMP 10 mice, optimized exploratory behavior in the open field test, diminished anxiety in elevated plus maze test, and improved retrieval of passive avoidance reaction.