Grigor'ev V V, Garibova T L, Voronina T A, Litvinova S A, Bachurin S O
Eksp Klin Farmakol. 2009 Jan-Feb;72(1):52-6.
SAMP 10 mice with genetically determined senescence (senescence-accelerated mouse prone 10) aged 16 months demonstrated (in comparison to 3-months old animals of the same strain) the following traits typical of old animal: behavior and memory deficiency, exploratory behavior impairment, and elevated level of anxiety. Dimebon administered for a long period of time with drinking water (1.5 mg/kg over 5 months) produced a positive action upon behavior and memory of 16-months-old SAMP 10 mice, optimized exploratory behavior in the open field test, diminished anxiety in elevated plus maze test, and improved retrieval of passive avoidance reaction.
16个月大的具有基因决定衰老特征的SAMP 10小鼠（衰老加速易感性小鼠10型）表现出（与同品系3个月大的动物相比）以下典型的老年动物特征：行为和记忆缺陷、探索行为受损以及焦虑水平升高。长期通过饮水给予Dimebon（5个月内1.5毫克/千克）对16个月大的SAMP 10小鼠的行为和记忆产生了积极作用，在旷场试验中优化了探索行为，在高架十字迷宫试验中减轻了焦虑，并改善了被动回避反应的恢复。
