Su Cheng-Kuan
Department of Chemistry, National Chung Hsing University, Taichung, 402, Taiwan.
Anal Chim Acta. 2021 May 8;1158:338348. doi: 10.1016/j.aca.2021.338348. Epub 2021 Feb 23.
Recent developments in three-dimensional printing (3DP) have attracted the attention of analytical scientists interested in fabricating 3D devices having promising geometric functions to achieve desirable analytical performance. To break through the barrier of limited availability of 3DP materials and to extend the chemical reactivity and functionalities of devices manufactured using conventional 3DP, new approaches are being developed for the functionalization of 3D-printed devices for chemical and biochemical analysis. This Review discusses recent advances in the chemical functionalization schemes used in the main 3DP technologies, including (i) post-printing modification and surface immobilization of reactive substances on printed materials, (ii) pre-printing incorporation of reactive substances into raw printing materials, and (iii) combinations of both strategies, and their effects on the selectivity and/or sensitivity of related analytical methods. In addition, the state of the art of 3D-printed functionalized analytical devices for enzymatic derivatization and sensing, electrochemical sensing, and sample pretreatment applications are also reviewed, highlighting the importance of introducing new functional and functionalized materials to facilitate future 3DP-enabled manufacturing of multifunctional analytical devices.
三维打印（3DP）的最新进展引起了分析科学家的关注，他们对制造具有前景的几何功能以实现理想分析性能的三维设备感兴趣。为了突破3DP材料可用性有限的障碍，并扩展使用传统3DP制造的设备的化学反应性和功能，正在开发用于化学和生化分析的三维打印设备功能化的新方法。本综述讨论了主要3DP技术中使用的化学功能化方案的最新进展，包括（i）印刷后对印刷材料上的反应性物质进行改性和表面固定，（ii）在印刷前将反应性物质掺入原始印刷材料中，以及（iii）两种策略的组合，以及它们对相关分析方法的选择性和/或灵敏度的影响。此外，还综述了用于酶促衍生化和传感、电化学传感以及样品预处理应用的三维打印功能化分析设备的现状，强调了引入新的功能和功能化材料对于促进未来基于3DP的多功能分析设备制造的重要性。
