Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA.
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, 420 Delaware St. SE, Minneapolis, MN 55455, USA.
Semin Diagn Pathol. 2021 Jul;38(4):14-20. doi: 10.1053/j.semdp.2021.03.006. Epub 2021 Mar 26.
The gastrointestinal (GI) tract is home to a significant portion of the immune system, which interacts daily with the antigenic milieu of its contents. Therefore, the presence of white blood cells within the walls of the GI tract upon histologic examination is a familiar sight on GI biopsies-both in health and disease. The GI tract is the most common site of extranodal lymphomas, most of which are B-cell neoplasms. Here, we review common and uncommon B-cell neoplasms of the GI tract - extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), mantle cell lymphoma, duodenal-type follicular lymphoma, diffuse large B-cell lymphoma, plasmablastic lymphoma, EBV-positive mucocutaneous ulcer, and post-transplant lymphoproliferative disorders - with special focus on literature published during the past five years. Along with the other articles in this edition of Seminars in Diagnostic Pathology, it is the authors' hope that this review proves to be a useful resource in the workup of the array of hematopoietic processes that can involve the GI tract.
胃肠道（GI）是免疫系统的重要组成部分，它每天与内容物的抗原环境相互作用。因此，在组织学检查中，GI 活检中胃肠道壁内出现白细胞是一种常见现象——无论是在健康还是疾病中。GI 是结外淋巴瘤最常见的部位，其中大多数是 B 细胞肿瘤。在这里，我们回顾了胃肠道的常见和不常见的 B 细胞肿瘤——黏膜相关淋巴组织（MALT 淋巴瘤）的结外边缘区淋巴瘤、套细胞淋巴瘤、十二指肠型滤泡性淋巴瘤、弥漫性大 B 细胞淋巴瘤、浆母细胞淋巴瘤、EBV 阳性黏膜溃疡性疾病和移植后淋巴组织增生性疾病——特别关注过去五年发表的文献。与本期《诊断病理学研讨会》中的其他文章一样，作者希望这篇综述能成为处理涉及胃肠道的一系列造血过程的有用资源。
