Saskatoon Cancer Centre, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, SK S7N 4H4, Canada.
Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 0W8, Canada.
Curr Oncol. 2022 Jul 18;29(7):5042-5053. doi: 10.3390/curroncol29070399.
Plasmablastic lymphoma is a rare subtype of large B-cell lymphoma characterised by an aggressive clinical course with frequent relapses and refractoriness to chemotherapy. It is usually associated with HIV, however, it can also be seen in immunocompetent patients. It has distinct pathological characteristics, such as plasmablastic morphology and lack of CD20 expression. These characteristics pose a clinical and pathological challenge. There is no standard of care established in this entity. In this case report, we described a novel bortezomib-based plasma cell targeted regimen in a HIV-negative patient refractory to chemotherapy.
浆母细胞淋巴瘤是一种罕见的大 B 细胞淋巴瘤亚型，其临床病程具有侵袭性，常频繁复发且对化疗有耐药性。它通常与 HIV 相关，但也可见于免疫功能正常的患者。它具有独特的病理特征，如浆母细胞形态和缺乏 CD20 表达。这些特征构成了临床和病理上的挑战。目前尚未在该实体中建立标准的治疗方法。在本病例报告中，我们描述了一种新型基于硼替佐米的浆细胞靶向方案，用于治疗对化疗耐药的 HIV 阴性患者。
