Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan; Ms.Clinic MayOne, Kashihara, Nara, Japan.
Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan.
Arch Med Res. 2021 Aug;52(6):641-647. doi: 10.1016/j.arcmed.2021.03.006. Epub 2021 Apr 15.
Recent studies have focused on the role of oxidative stress, which may be implicated in the development, progression, and pathophysiology of endometriosis.
The aim of this study is to investigate the redox balance of endometriosis by simultaneously measuring iron-related compounds (total iron, heme iron, free iron, oxyhemoglobin [oxyHb], methemoglobin [metHb] and 8-hydroxy-2-deoxy guanosine [8-OHdG]) and antioxidants (bilirubin, heme oxygenase-1 [HO-1] and total antioxidant capacity [TAC]).
This study includes 236 histopathologically confirmed cases (178 cases of endometriosis and 58 cases of non-endometriosis). Cyst fluid samples were collected from patients admitted to the Department of Gynecology, Nara Medical University, Kashihara, Japan, for surgery.
Age at diagnosis (p <0.001), the maximum diameter of the cyst (p <0.001) and CA125 levels (p <0.001) differed significantly between the two groups. Total iron, heme iron, free iron, metHb, and oxyHb were markedly higher in endometriosis compared to non-endometriosis. Bilirubin, HO-1 and TAC were significantly higher in endometriosis patients compared with those from non-endometriosis patients. In endometriosis, total iron showed a positive correlation with HO-1 (r, 0.518, p = 0.001), but there were no antioxidants that correlated with iron in non-endometriosis. Iron and HO-1 did not correlate with age or tumor size.
HO-1 may regulate the delicate balance of iron-induced oxidative stress in endometriotic cyst fluid.
最近的研究集中在氧化应激的作用上，氧化应激可能与子宫内膜异位症的发展、进展和病理生理学有关。
本研究旨在通过同时测量铁相关化合物（总铁、血红素铁、游离铁、氧合血红蛋白[oxyHb]、高铁血红蛋白[metHb]和 8-羟基-2-脱氧鸟苷[8-OHdG]）和抗氧化剂（胆红素、血红素加氧酶-1[HO-1]和总抗氧化能力[TAC]）来研究子宫内膜异位症的氧化还原平衡。
本研究包括 236 例经组织病理学证实的病例（178 例子宫内膜异位症和 58 例非子宫内膜异位症）。从日本奈良医科大学妇产科因手术入院的患者中采集囊液样本。
两组间诊断时的年龄（p<0.001）、囊肿的最大直径（p<0.001）和 CA125 水平（p<0.001）差异显著。与非子宫内膜异位症相比，子宫内膜异位症患者的总铁、血红素铁、游离铁、高铁血红蛋白和氧合血红蛋白明显升高。与非子宫内膜异位症患者相比，子宫内膜异位症患者的胆红素、HO-1 和 TAC 明显升高。在子宫内膜异位症中，总铁与 HO-1 呈正相关（r，0.518，p=0.001），而非子宫内膜异位症中没有与铁相关的抗氧化剂。铁和 HO-1 与年龄或肿瘤大小无关。
HO-1 可能调节子宫内膜异位症囊液中铁诱导的氧化应激的微妙平衡。
