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Evolution of the Human Cytokine Response from Acute Illness to Disease Resolution in SARS-Cov-2 Infection-Implications for Therapeutic Monitoring and Therapeutic Targets.

作者信息

Drewett George P, Copaescu Ana, Mouhtouris Effie, Hannan Natalie, James Fiona, Smibert Olivia, Holmes Natasha E, Trubiano Jason A

机构信息

Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.

Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.

出版信息

J Clin Immunol. 2021 Aug;41(6):1162-1164. doi: 10.1007/s10875-021-01039-x. Epub 2021 Apr 16.

DOI:10.1007/s10875-021-01039-x
PMID:33864183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8051826/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0d9/8051826/4758c2a9a6cc/10875_2021_1039_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0d9/8051826/4758c2a9a6cc/10875_2021_1039_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0d9/8051826/4758c2a9a6cc/10875_2021_1039_Fig1_HTML.jpg

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本文引用的文献

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N Engl J Med. 2021 Apr 22;384(16):1491-1502. doi: 10.1056/NEJMoa2100433. Epub 2021 Feb 25.
2
Immunopathology of Hyperinflammation in COVID-19.COVID-19 中的过度炎症的免疫病理学。
Am J Pathol. 2021 Jan;191(1):4-17. doi: 10.1016/j.ajpath.2020.08.009. Epub 2020 Sep 11.
3
The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection.白细胞介素 6 及其他介质在与 SARS-CoV-2 感染相关的细胞因子风暴中的作用。
J Allergy Clin Immunol. 2020 Sep;146(3):518-534.e1. doi: 10.1016/j.jaci.2020.07.001.
4
An inflammatory cytokine signature predicts COVID-19 severity and survival.炎症细胞因子特征可预测 COVID-19 严重程度和存活情况。
Nat Med. 2020 Oct;26(10):1636-1643. doi: 10.1038/s41591-020-1051-9. Epub 2020 Aug 24.
5
Clinical and immunological features of severe and moderate coronavirus disease 2019.新型冠状病毒病 2019 重症和中度患者的临床和免疫学特征。
J Clin Invest. 2020 May 1;130(5):2620-2629. doi: 10.1172/JCI137244.
6
Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS.SARS患者中SARS-CoV感染的ACE2+细胞中促炎细胞因子水平升高的表达：与SARS急性肺损伤和发病机制的关系。
J Pathol. 2006 Nov;210(3):288-97. doi: 10.1002/path.2067.