Department of Haematology, Odense University Hospital, Odense, Denmark.
Department of Haematology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Crit Rev Oncol Hematol. 2021 May;161:103341. doi: 10.1016/j.critrevonc.2021.103341. Epub 2021 Apr 15.
Over the last decade, several prognostic models have been proposed for primary central nervous system lymphoma (PCNSL), but consensus on the optimal model for these patients is absent or lacking. This study aims to review available prognostic models for PCNSL and discuss their prognostic features. A comprehensive literature search performed in Pubmed/Embase identified ten studies with a variable number of analysed patients (range 32-3453), which proposed 12 prognostic models. Age and performance status were the most important prognostic factors in PCNSL and an integral part of the majority of the proposed models. However, there is no universally accepted prognostic model for PCNSL owning to a number of limitations such as a small number of patients, limited samples obtained for genetic analysis, retrospective nature of studies, single centre studies, and lack of validation. Future multicentre studies are necessary to determine the optimal prognostic model for PCNSL by combining different prognostic markers of significance.
在过去的十年中，已经提出了几种用于原发性中枢神经系统淋巴瘤（PCNSL）的预后模型，但对于这些患者的最佳模型还没有共识或缺乏共识。本研究旨在回顾 PCNSL 的现有预后模型，并讨论其预后特征。在 Pubmed/Embase 中进行的全面文献检索确定了十项研究，这些研究分析了不同数量的患者（范围为 32-3453），提出了 12 种预后模型。年龄和表现状态是 PCNSL 最重要的预后因素，也是大多数提出的模型的重要组成部分。然而，由于存在许多局限性，例如患者数量少、遗传分析获得的样本有限、研究的回顾性、单中心研究以及缺乏验证，目前还没有被普遍接受的 PCNSL 预后模型。未来的多中心研究有必要通过结合不同具有重要意义的预后标志物来确定 PCNSL 的最佳预后模型。
