Department of Radiology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501 Japan.
Hell J Nucl Med. 2021 Jan-Apr;24(1):36-44. doi: 10.1967/s002449912304. Epub 2021 Apr 20.
To evaluate the clinical utility of quantitative values obtained with bone single photon emission computed tomography/computed tomography (SPECT/CT) for primary bone neoplasms.
Bone SPECT/CT scans of 23 patients with 19 benign bone neoplasms (5 osteoid osteomas, 4 bone giant cell tumor, 4 osteofibrous dysplasia, 3 intraosseous ganglion, 2 aneurysmal bone cyst, 1 intraosseous hemangioma) and 5 malignant bone neoplasms (2 osteosarcoma, 1 periosteal osteosarcoma, 1 malignancy in bone giant cell tumor, 1 Ewing sarcoma) were retrospectively analyzed with maximum standardized uptake value (SUVmax), peak SUV (SUVpeak), mean SUV (SUVmean), metabolic bone volume (MBV), and total bone uptake (TBU) of primary lesions.
Mean SUVmax of 19 benign and 5 malignant primary bone neoplasms were 6.89±3.26 (range 3.9-15.13) and 10.31±3.19 (5.0-13.45) respectively, with statistically significant difference (P=0.048). Mean SUVpeak of those were 5.87±2.83 (range 3.5-13.63) and 9.18±3.05 (4.09-12.03) respectively, with statistically significant difference (P=0.032). Mean SUVmean of those were 4.43±2.11 (range 2.59-9.37) and 7.13±2.90 (3.3-10.42) respectively, with statistically significant difference (P=0.027). Mean MBV of those were 22.0±30.0 (range 2.47-110.61) and 27.8±39.94 (8.59-99.24) respectively, with no statistically significant difference (P=0.72). Mean TBU of those were 80.64±94.57 (range 10.50-373.57) and 166.60±203.97 (28.68-528.13) respectively, with no statistically significant difference (P=0.17).
Quantitative values obtained with bone SPECT/CT may serve as osteoblastic biomarkers for primary bone neoplasm.
评估骨单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）定量值在原发性骨肿瘤中的临床应用价值。
回顾性分析 23 例患者的骨 SPECT/CT 扫描，其中 19 例为良性骨肿瘤（5 例骨样骨瘤、4 例骨巨细胞瘤、4 例骨纤维结构不良、3 例骨内神经节瘤、2 例骨囊肿、1 例骨内血管瘤）和 5 例恶性骨肿瘤（2 例骨肉瘤、1 例骨膜骨肉瘤、1 例骨巨细胞瘤恶变、1 例尤文肉瘤）。分析原发性病变的最大标准化摄取值（SUVmax）、峰值 SUV（SUVpeak）、平均 SUV（SUVmean）、代谢性骨体积（MBV）和总骨摄取（TBU）。
19 例良性和 5 例恶性原发性骨肿瘤的 SUVmax 均值分别为 6.89±3.26（范围 3.9-15.13）和 10.31±3.19（5.0-13.45），差异有统计学意义（P=0.048）。SUVpeak 的均值分别为 5.87±2.83（范围 3.5-13.63）和 9.18±3.05（4.09-12.03），差异有统计学意义（P=0.032）。SUVmean 的均值分别为 4.43±2.11（范围 2.59-9.37）和 7.13±2.90（3.3-10.42），差异有统计学意义（P=0.027）。MBV 的均值分别为 22.0±30.0（范围 2.47-110.61）和 27.8±39.94（8.59-99.24），差异无统计学意义（P=0.72）。TBU 的均值分别为 80.64±94.57（范围 10.50-373.57）和 166.60±203.97（28.68-528.13），差异无统计学意义（P=0.17）。
骨 SPECT/CT 定量值可作为原发性骨肿瘤成骨性生物标志物。
