Yamane Tomohiko, Takahashi Masafumi, Matsusaka Yohji, Fukushima Kenji, Seto Akira, Kuji Ichiei, Matsunari Ichiro
Division of Nuclear Medicine, Department of Radiology, Saitama Medical University Hospital, 38 Moro-Hongo, Moroyama, 350-0495, Japan.
Department of Nuclear Medicine, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, 350-0491, Japan.
Sci Rep. 2021 Dec 21;11(1):24320. doi: 10.1038/s41598-021-03853-0.
The aim of this study was to evaluate the quantitative values of short-time scan (STS) of metastatic lesions compared with a standard scan (SS) when acquired by whole-body bone SPECT/CT with cadmium-zinc-telluride (CZT) detectors. We retrospectively reviewed 13 patients with bone metastases from prostate cancer, who underwent SPECT/CT performed on whole-body CZT gamma cameras. STSs were obtained using 75, 50, 25, 10, and 5% of the list-mode data for SS, respectively. Regions of interest (ROIs) were set on the increased uptake areas diagnosed as metastases. Intraclass correlation coefficients (ICCs) of standardized uptake values (SUVs) for the ROIs were calculated between the SS and each STS, and ICC ≥ 0.8 was set as a perfect correlation. Moreover, the repeatability coefficient (RC) was calculated, and RC ≤ 20% was defined as acceptable. A total of 152 metastatic lesions were included in the analysis. The ICCs between the SS vs. 75%-STS, 50%-STS, 25%-STS, 10%-STS, and 5%-STS were 0.999, 0.997, 0.994, 0.983, and 0.955, respectively. The RCs of the SS vs. 75%-STS, 50%-STS, 25%-STS, 10%-STS, and 5%-STS were 7.9, 12.4, 19.8, 30.8, and 41.3%, respectively. When evaluating the quality of CZT bone SPECT/CT acquired by a standard protocol, 25%-STS may provide adequate quantitative values.
本研究的目的是评估当使用碲化镉锌（CZT）探测器的全身骨SPECT/CT进行采集时，与标准扫描（SS）相比，转移性病变的短时间扫描（STS）的定量值。我们回顾性分析了13例前列腺癌骨转移患者，这些患者在全身CZT伽马相机上进行了SPECT/CT检查。分别使用SS列表模式数据的75%、50%、25%、10%和5%获得STS。在诊断为转移的摄取增加区域设置感兴趣区（ROI）。计算SS与每个STS之间ROI的标准化摄取值（SUV）的组内相关系数（ICC），并将ICC≥0.8设定为完美相关。此外，计算重复性系数（RC），并将RC≤20%定义为可接受。分析共纳入152个转移性病变。SS与75% - STS、50% - STS、25% - STS、10% - STS和5% - STS之间的ICC分别为0.999、0.997、0.994、0.983和0.955。SS与75% - STS、50% - STS、25% - STS、10% - STS和5% - STS的RC分别为7.9%、12.4%、19.8%、30.8%和41.3%。在评估通过标准方案获得的CZT骨SPECT/CT的质量时，25% - STS可能提供足够的定量值。
