Mashaal Kiran, Perveen Rehana, Zia Zubia, Mahmood Syed Muhammad, Minhas Khurram, Ibrahim Sadaf, Hasan Naqvi Syed Naim Ul, Naeem Hira
Department of Pharmacology, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, 51 Deh Tor, Gadap Road, Near Toll Plaza, Super Highway, Karachi, Pakistan.
Department of Oncology, Aga Khan University Hospital, Karachi, Pakistan.
Pak J Pharm Sci. 2020 Nov;33(6):2483-2488.
Cedrus deodara have been used traditionally in ayurvedic system against peptic ulcer. Present work is concerned with the determination of histopathological effects in ethanol induced ulcer on rats (Wistar Strain) treated with Cedrus deodara root oil at a dose of 200mg/kg and comparison of its antiulcer activity against control, positive control and standard anti-ulcer drug (Omeprazole). The aim was to find out the antiulcer effect of Cedrus deodara root oil and to observe histopathology of liver, kidney as well. 120 Albino rats were taken and divided into four groups i.e. A, B, C and D designated as control, positive control, standard and treated groups respectively. Normal and intact general architecture of mucosa and submucosa layers of stomach observed. No significant changes observed in thickness of epithelium, no inflammatory cells were present on the mucosa and submucosal layer and gastric glands were normal. Liver of albino rats, showed no dilation and congestion in central as well as portal vein. Kidney of albino rats exhibited no shrinkage in glomeruli, no congested and dilated renal corpuscles, neither hemolysis nor congested and dilated renal tubules were seen. It is concluded that C. deodara root oil has anti-ulcer properties without effecting kidney and liver tissues.
雪松在阿育吠陀医学体系中传统上被用于治疗消化性溃疡。目前的研究工作涉及测定雪松根油以200mg/kg的剂量对乙醇诱导的大鼠（Wistar品系）溃疡的组织病理学影响，并将其抗溃疡活性与对照组、阳性对照组和标准抗溃疡药物（奥美拉唑）进行比较。目的是找出雪松根油的抗溃疡作用，并观察肝脏和肾脏的组织病理学。选取120只白化大鼠，分为四组，即A组、B组、C组和D组，分别指定为对照组、阳性对照组、标准组和治疗组。观察到胃黏膜和黏膜下层的正常且完整的总体结构。上皮厚度未见明显变化，黏膜和黏膜下层未见炎性细胞，胃腺正常。白化大鼠的肝脏，中央静脉和门静脉均未见扩张和充血。白化大鼠的肾脏，肾小球未见萎缩，肾小体未见充血和扩张，未见溶血现象，肾小管未见充血和扩张。结论是雪松根油具有抗溃疡特性，且对肾脏和肝脏组织无影响。
