Abbas Afshan, Ikram Rahila, Hasan Faiza, Sarfaraz Sana, Bukhari Qurrat Ul Ain
Department Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
Pak J Pharm Sci. 2020 Nov;33(6):2595-2600.
The objective of this study was to evaluate the effect of Foeniculum vulgare (FV) on fertility of mice and on serum sex hormone values of rats and rabbits. We used powdered form of Foeniculum vulgare seed and added it to food of mice, rats and rabbits in 2% and 4% ratio which was provided ad libitum throughout study period. Fertility study on mice was conducted for a period of nine months and 3 generations of mice fed on study drug were observed. Rats and rabbits were given Foeniculum vulgare seed powder containing diet for two month and then serum levels of FSH, LH, estrogen, progesterone and testosterone were checked. The number of pups increased in each succeeding generation and no gross abnormality was observed in any of the pups of all 3 generations. The sex hormone levels increased in both sexes of rats and rabbits with exception of FSH and LH levels which were less than 0.1mIU/mL in all study animals. Data was analysed on SPSS. Fertility and sex hormones increased in both male and female when given special diet containing 2% and 4% Foeniculum vulgare.
本研究的目的是评估小茴香（FV）对小鼠生育能力以及对大鼠和家兔血清性激素值的影响。我们使用小茴香种子粉末，并以2%和4%的比例将其添加到小鼠、大鼠和家兔的食物中，在整个研究期间随意提供。对小鼠进行了为期九个月的生育能力研究，并观察了三代食用受试药物的小鼠。给大鼠和家兔喂食含小茴香种子粉末的饮食两个月，然后检查血清促卵泡生成素（FSH）、促黄体生成素（LH）、雌激素、孕酮和睾酮水平。每一代后代的幼崽数量都有所增加，并且在所有三代的任何幼崽中均未观察到明显异常。除了所有研究动物的FSH和LH水平均低于0.1mIU/mL外，大鼠和家兔两性的性激素水平均有所升高。数据在SPSS上进行分析。当给予含有2%和4%小茴香的特殊饮食时，雄性和雌性的生育能力和性激素均有所增加。
