Mandal Raju Kumar, Mittal Rama Devi
Research and Scientific Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia.
Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Indian J Clin Biochem. 2021 Apr;36(2):175-184. doi: 10.1007/s12291-020-00877-7. Epub 2020 Mar 2.
X-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision repair pathway, as a scaffold protein that brings together proteins of the DNA repair complex. Several studies have reported contradictory results for exon 6 C>T (rs1799782) gene polymorphism and cancer risk in Indian population has provided inconsistent results. Therefore, we have performed this meta-analysis to evaluate the relationship between exon 6 C>T gene polymorphism and risk of cancer by published studies. We searched PubMed and Google scholar web databases to cover all studies published on association between exon 6 C>T gene polymorphism and cancer risk. The meta-analysis was carried out and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to appraise the strength of association. In order to derive a more precise estimation of the association, A total of 3197 confirmed cancer cases and 3819 controls were included from eligible seventeen case-controls studies. Results from overall pooled analysis demonstrated suggested that that variant allele (T vs. C: OR 1.301, 95% CI 1.003-1.688, = 0.047) was associated with the risk of overall cancer. Other genetic models; heterozygous (TC vs. CC: OR 1.108, 95% CI 0.827-1.485, = 0.491), homozygous (TT vs. CC: OR 1.479, 95% CI 0.877-2.493, = 0.142), dominant (TT+TC vs. CC: OR 1.228, 95% CI 0.899-1.677, = 0.196) and recessive (TT vs. TC+CC: OR 1.436, 95% CI 0.970-2.125, = 0.071) did not reveal statistical association. Publication bias observation was also considered and none was detected during the analysis. The present meta-analysis suggested that the variant allele T of exon 6 gene polymorphism was associated with the risk of cancer. It is therefore pertinent to confirm this finding in a large sample size to divulge the mechanism of this polymorphism and cancer risk in Indian population.
X射线修复交叉互补基因1（XRCC1）在碱基切除修复途径中起关键作用，作为一种支架蛋白，它能将DNA修复复合物中的蛋白质聚集在一起。多项研究报告了外显子6 C>T（rs1799782）基因多态性与印度人群癌症风险之间相互矛盾的结果。因此，我们进行了这项荟萃分析，以通过已发表的研究评估外显子6 C>T基因多态性与癌症风险之间的关系。我们检索了PubMed和谷歌学术网络数据库，以涵盖所有关于外显子6 C>T基因多态性与癌症风险关联的已发表研究。进行了荟萃分析，并使用合并优势比（OR）和95%置信区间（95%CI）来评估关联强度。为了更精确地估计这种关联，从符合条件的17项病例对照研究中纳入了总共3197例确诊癌症病例和3819例对照。总体合并分析结果表明，变异等位基因（T与C：OR 1.301，95%CI 1.003 - 1.688，P = 0.047）与总体癌症风险相关。其他遗传模型；杂合子（TC与CC：OR 1.108，95%CI 0.827 - 1.485，P = 0.491）、纯合子（TT与CC：OR 1.479，95%CI 0.877 - 2.493，P = 0.142）、显性（TT + TC与CC：OR 1.228，95%CI 0.899 - 1.677，P = 0.196）和隐性（TT与TC + CC：OR 1.436，95%CI 0.970 - 2.125，P = 0.071）均未显示出统计学关联。还考虑了发表偏倚观察，分析过程中未检测到。本荟萃分析表明，外显子6基因多态性的变异等位基因T与癌症风险相关。因此，有必要在大样本中证实这一发现，以揭示印度人群中这种多态性与癌症风险的机制。
