北印度人群中[具体基因]和单核苷酸多态性与膀胱癌风险的关联：一项初步研究。 （你原文中“Association of and ”这里有缺失信息，我按格式补充了[具体基因]，实际翻译时需根据完整信息准确翻译）
Association of and SNPs with Bladder Cancer Risk in North Indian Population: A Pilot Study.
作者信息
Verma Archana, Mittal Rama Devi
机构信息
Department of Ocular Oncology, L V Prasad Eye Institute, Banjara Hills, Hyderabad, Telangana 500034 India.
Professor and Emeritus Medical Scientist (ICMR), Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh 226014 India.
出版信息
Indian J Clin Biochem. 2021 Apr;36(2):194-199. doi: 10.1007/s12291-020-00881-x. Epub 2020 Apr 4.
miRNA play role in post transcriptional regulation of genes and serves a range of biological functions such as initiation, development, metastasis etc. which are also hallmarks of cancer. Hence, we evaluated miRNA 181a, miRNA 30c and miRNA 570 in bladder cancer risk association among North Indians. miRNA 570 C/G (rs4143815), miRNA 30c A/G (rs928508) and miRNA 181a C/T (rs12537) single nucleotide polymorphisms (SNPs) were genotyped by allelic discrimination TaqMan assay in 100 bladder cancer (BC) patients and 100 healthy controls. No significant difference was found in the genotype frequencies of the candidate SNPs among cases and controls. However, combined effect of miRNA 570-miRNA 30c (CG + AA) = 0.005, OR = 0.223, 95% CI and miRNA 570-miRNA 181a (CG + CC) = 0.003, OR = 0.169, 95% CI conferred association with no risk of BC. miRNA 181a C/T (rs12537), miRNA 30c A/G (rs928508) and miRNA 570 C/G (rs4143815) should be further validated in large sample size to be used as a risk predictor for bladder cancer among North Indians.
微小RNA（miRNA）在基因的转录后调控中发挥作用，并具有一系列生物学功能，如启动、发育、转移等，这些也是癌症的特征。因此，我们评估了北印度人群中miRNA 181a、miRNA 30c和miRNA 570与膀胱癌风险的关联。通过等位基因鉴别TaqMan分析法对100例膀胱癌（BC）患者和100例健康对照进行基因分型，检测miRNA 570 C/G（rs4143815）、miRNA 30c A/G（rs928508）和miRNA 181a C/T（rs12537）单核苷酸多态性（SNP）。病例组和对照组中候选SNP的基因型频率未发现显著差异。然而，miRNA 570-miRNA 30c（CG + AA）= 0.005，OR = 0.223，95% CI以及miRNA 570-miRNA 181a（CG + CC）= 0.003，OR = 0.169，95% CI显示与无膀胱癌风险相关。miRNA 181a C/T（rs12537）、miRNA 30c A/G（rs928508）和miRNA 570 C/G（rs4143815）应在大样本中进一步验证，以用作北印度人群膀胱癌的风险预测指标。
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