Genetic Variation in Gene and Its Association with Bladder Cancer Risk in North Indian Population.

Adhesion molecules play a key role in cancer progression and tumorigenesis. Genetic polymorphism of adhesion molecules may alter the normal functioning thereby leading to bladder cancer susceptibility. Hence we aimed to evaluate three SNPs of gene and in bladder cancer patients and normal controls of North Indian population. A total of 270 healthy controls and 240 confirmed bladder cancer patients were recruited for this study. Three SNPs of gene viz. and were selected for this study. and were genotyped by Taqman allelic discrimination assay and was genotyped by PCR-RFLP. The statistical analysis was done using the SPSS software, version 16.0 (SPSS, Chicago, IL), and  < 0.05 was considered statistically significant. Haplotypic analysis was done by using SNP analyzer version 1.2A. and showed significant association with reduced risk in bladder cancer while showed significant high risk along with association at genotypic and allelic levels. Haplotypic analysis showed 1.8-folds risk in CCG combination, whereas CTA and TCG showed significant association with reduced risk. Further stratification on the basis of smoking, tumor grade/stage and BGC therapy revealed no association of these three polymorphic sites of . Our study suggests that and are predictive for the reduced risk of bladder cancer, whereas had shown significant association with high risk of bladder cancer in North Indians. This somehow suggests that can be used as a marker for risk prediction of bladder cancer.