Balázs M, Schwarzberg H, Penke B, Telegdy G
Department of Pathophysiology, University Medical School, Szeged, Hungary.
Neuropeptides. 1988 Apr;11(3):143-5. doi: 10.1016/0143-4179(88)90084-4.
The effects of cholecystokinin octapeptide sulfate ester (CCK-8-SE), its N-terminal tripeptide (CCK-2-4-SE) and its C-terminal tetrapeptide (CCK-5-8) were investigated on hypothalamic self-stimulation in rats. CCK-8-SE and CCK-5-8 in 400 pmole doses inhibited self-stimulation behaviour, while CCK-2-4-SE was ineffective. In 80 pmole doses the peptides showed no effect. It is suggested that CCK-5-8 itself influences self-stimulation behaviour.
研究了硫酸缩胆囊素八肽（CCK - 8 - SE）、其N端三肽（CCK - 2 - 4 - SE）和C端四肽（CCK - 5 - 8）对大鼠下丘脑自身刺激行为的影响。400皮摩尔剂量的CCK - 8 - SE和CCK - 5 - 8抑制了自身刺激行为，而CCK - 2 - 4 - SE无效。80皮摩尔剂量时，这些肽无作用。提示CCK - 5 - 8本身影响自身刺激行为。
