Fekete M, Rentzsch A, Schwarzberg H, Telegdy G
Eur J Pharmacol. 1983 Jul 15;91(1):77-82. doi: 10.1016/0014-2999(83)90364-3.
Experiments were performed to examine the effects of intracerebroventricularly administered cholecystokinin octapeptide sulfate ester (CCK-8-SE) and unsulfated cholecystokinin octapeptide (CCK-8-NS) on electrical self-stimulation behavior elicited from the medial forebrain bundle. CCK-8-SE and CCK-8-NS in 80 pmol doses reduced the response rate of self-stimulation behavior 22-30 min following injection, while 400 pmol doses of these peptides attenuated self-stimulation behavior between 13 and 36 min. It is suggested that CCK-8-SE and CCK-8-NS interact with central rather than peripheral nervous mechanisms.
进行实验以研究脑室内注射硫酸化八肽胆囊收缩素（CCK-8-SE）和非硫酸化八肽胆囊收缩素（CCK-8-NS）对内侧前脑束引发的电刺激自身行为的影响。80皮摩尔剂量的CCK-8-SE和CCK-8-NS在注射后22 - 30分钟降低了自身刺激行为的反应率，而400皮摩尔剂量的这些肽在13至36分钟之间减弱了自身刺激行为。提示CCK-8-SE和CCK-8-NS与中枢而非外周神经机制相互作用。
