Ettenberg A, Koob G F
Physiol Behav. 1984 Jan;32(1):127-30. doi: 10.1016/0031-9384(84)90083-0.
The effects of cholecystokinin (CCK) and satiety were compared in animals lever-pressing for rewarding electrical stimulation of the lateral hypothalamus. For some rats, conditions of food deprivation and satiation, respectively, increased or decreased responding whereas the self-stimulation behavior of other rats was unresponsive to these feeding manipulations. CCK, at doses thought to signal satiety, reduced the responding of all rats independent of whether they were, or were not, responsive to real satiety. This same result was obtained with the aversive agent lithium chloride. These data suggest that the reduced feeding observed following CCK administration is due to aversive consequences and not satiety.
在通过按压杠杆以获取对下丘脑外侧进行电刺激奖赏的动物中，比较了胆囊收缩素（CCK）和饱腹感的作用。对于一些大鼠，分别处于食物剥夺和饱腹状态时，反应会增加或减少，而其他大鼠的自我刺激行为对这些进食操作没有反应。CCK在被认为能表明饱腹感的剂量下，降低了所有大鼠的反应，无论它们是否对真正的饱腹感有反应。用厌恶剂氯化锂也得到了相同的结果。这些数据表明，CCK给药后观察到的进食减少是由于厌恶后果而非饱腹感。
