Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Murdoch Children's Research Institute, Parkville, VIC, Australia.
Front Immunol. 2021 Apr 2;12:646677. doi: 10.3389/fimmu.2021.646677. eCollection 2021.
The humoral response to vaccinations varies widely between individuals. There is no data available on the correlation between responses to different vaccines. In this study, we investigated the correlation of antibody responses between routine vaccine antigens in infants.
One and seven months after the 6-month vaccinations and one month after the 12-month vaccinations, antibody concentrations to diphtheria, tetanus, pertussis, polio (serotypes 1-3), type b (Hib), pneumococcus (13 serotypes), meningococcus C, measles, mumps and rubella were measured using fluorescent bead-based multiplex immune-assays. For the correlation of antibody responses, Spearman's rank correlation coefficients (ρ) with 95% confidence intervals (CI) were calculated between responses to each vaccine antigen.
The correlation between concentrations of antibodies to the vaccinations ending at 6 months of age was higher one month compared to seven months after vaccination. The strongest correlations at both time points were observed between antibody responses to different polio serotypes, certain pneumococcal serotypes and between responses to diphtheria and pneumococcal (conjugated to a diphtheria toxoid) vaccine antigens. Correlation between responses to tetanus, Hib, pertussis, polio and other vaccine antigens were weak. The correlation between antibody responses to the 12-month vaccine antigens was weaker than to the 6-month vaccine antigens and there was a negative correlation between responses to measles, mumps, rubella vaccine and non-live vaccine antigens (meningococcus C, tetanus and Hib). There was only weak correlation between antibody responses to vaccines of the same type (e.g. conjugated polysaccharide or toxoid vaccines).
Correlation between antibody responses to similar antigens in the same vaccine (such as different serotypes of a bacteria or virus), as well as responses to antigens conjugated to similar carrier proteins, are strong. In contrast, correlation between responses to other vaccines are weak. Measuring antibody responses to one or a few vaccine antigens therefore does not offer a reliable surrogate marker of responses to unrelated vaccines.
个体之间对疫苗的体液反应差异很大。目前尚无关于不同疫苗反应之间相关性的数据。在这项研究中，我们调查了婴儿常规疫苗抗原之间抗体反应的相关性。
在 6 个月疫苗接种后 1 个月和 7 个月，以及 12 个月疫苗接种后 1 个月，使用荧光珠基多重免疫分析测定对白喉、破伤风、百日咳、脊髓灰质炎（血清型 1-3）、b 型（Hib）、肺炎球菌（13 种血清型）、脑膜炎球菌 C、麻疹、腮腺炎和风疹的抗体浓度。为了评估抗体反应的相关性，使用 Spearman 秩相关系数（ρ）计算了每个疫苗抗原之间的反应。
与接种后 7 个月相比，6 个月龄时接种疫苗的抗体浓度之间的相关性在接种后 1 个月更高。在两个时间点，抗体反应之间最强的相关性是观察到不同脊髓灰质炎血清型、某些肺炎球菌血清型和白喉与肺炎球菌（与白喉类毒素结合）疫苗抗原之间的相关性。破伤风、Hib、百日咳、脊髓灰质炎和其他疫苗抗原之间的相关性较弱。与 12 个月龄疫苗抗原的反应相关性比 6 个月龄疫苗抗原弱，并且麻疹、腮腺炎、风疹疫苗与非活疫苗抗原（脑膜炎球菌 C、破伤风和 Hib）之间存在负相关。同种疫苗（如结合多糖或类毒素疫苗）的抗体反应之间相关性较弱。
同种疫苗（如不同细菌或病毒的血清型）相似抗原之间的抗体反应以及与相似载体蛋白结合的抗原之间的反应具有很强的相关性。相比之下，对其他疫苗的反应相关性较弱。因此，测量对一种或几种疫苗抗原的抗体反应并不能提供对不相关疫苗反应的可靠替代标志物。
