Department of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX, United States.
Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, United States.
Front Immunol. 2021 Mar 31;12:652687. doi: 10.3389/fimmu.2021.652687. eCollection 2021.
T cells undergo metabolic reprogramming and multiple biological processes to satisfy their energetic and biosynthetic demands throughout their lifespan. Several of these metabolic pathways result in the generation of reactive oxygen species (ROS). The imbalance between ROS generation and scavenging could result in severe damage to the cells and potential cell death, ultimately leading to T cell-related diseases. Interestingly, ROS play an essential role in T cell immunity. Here, we introduce the important connectivity between T cell lifespan and the metabolic reprogramming among distinct T cell subsets. We also discuss the generation and sources of ROS production within T cell immunity as well as highlight recent research concerning the effects of ROS on T cell activities.
T 细胞在其整个生命周期中经历代谢重编程和多种生物学过程，以满足其能量和生物合成需求。这些代谢途径中的几种会导致活性氧（ROS）的产生。ROS 的产生和清除之间的失衡可能导致细胞严重损伤和潜在的细胞死亡，最终导致与 T 细胞相关的疾病。有趣的是，ROS 在 T 细胞免疫中发挥着重要作用。在这里，我们介绍了 T 细胞寿命与不同 T 细胞亚群之间代谢重编程之间的重要联系。我们还讨论了 T 细胞免疫中 ROS 的产生和来源，并强调了最近关于 ROS 对 T 细胞活性影响的研究。
