Gwen Knapp Center for Lupus and Immunology Research, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, United States.
Front Immunol. 2021 Mar 31;12:659151. doi: 10.3389/fimmu.2021.659151. eCollection 2021.
Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. In this review, we highlight advances that demonstrate that fundamental GC B cell function, selection, proliferation and SHM occur within distinct cell states. The resulting new model provides new opportunities to understand the evolution of immunity in infectious, autoimmune and neoplastic diseases.
保护性高亲和力抗体反应是通过生发中心（GC）中的一个协调的发育过程产生的。虽然 GC 自 1930 年以来就已被人们所认识，但最近的大量进展为控制体液免疫的分子和细胞动力学提供了新的见解。在这篇综述中，我们强调了一些进展，这些进展表明基本的 GC B 细胞功能、选择、增殖和 SHM 发生在不同的细胞状态中。由此产生的新模型为理解传染病、自身免疫和肿瘤疾病中的免疫进化提供了新的机会。
