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基于纳米生物技术的新型放射增敏剂在胶质瘤治疗中的应用

Application of New Radiosensitizer Based on Nano-Biotechnology in the Treatment of Glioma.

作者信息

Xie Yandong, Han Yuhan, Zhang Xuefeng, Ma Hongwei, Li Linfeng, Yu Rutong, Liu Hongmei

机构信息

Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou, China.

Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

出版信息

Front Oncol. 2021 Mar 22;11:633827. doi: 10.3389/fonc.2021.633827. eCollection 2021.

Abstract

Glioma is the most common intracranial malignant tumor, and its specific pathogenesis has been unclear, which has always been an unresolved clinical problem due to the limited therapeutic window of glioma. As we all know, surgical resection, chemotherapy, and radiotherapy are the main treatment methods for glioma. With the development of clinical trials and traditional treatment techniques, radiotherapy for glioma has increasingly exposed defects in the treatment effect. In order to improve the bottleneck of radiotherapy for glioma, people have done a lot of work; among this, nano-radiosensitizers have offered a novel and potential treatment method. Compared with conventional radiotherapy, nanotechnology can overcome the blood-brain barrier and improve the sensitivity of glioma to radiotherapy. This paper focuses on the research progress of nano-radiosensitizers in radiotherapy for glioma.

摘要

胶质瘤是最常见的颅内恶性肿瘤,其具体发病机制尚不清楚,由于胶质瘤的治疗窗口有限,这一直是一个未解决的临床问题。众所周知,手术切除、化疗和放疗是胶质瘤的主要治疗方法。随着临床试验和传统治疗技术的发展,胶质瘤放疗在治疗效果上越来越多地暴露出缺陷。为了改善胶质瘤放疗的瓶颈,人们做了大量工作;其中,纳米放射增敏剂提供了一种新颖且有潜力的治疗方法。与传统放疗相比,纳米技术可以克服血脑屏障,提高胶质瘤对放疗的敏感性。本文重点介绍纳米放射增敏剂在胶质瘤放疗中的研究进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de6/8044949/b1787a0c24da/fonc-11-633827-g001.jpg

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