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使用无系留软机器人微型设备研究组织力学

Investigating Tissue Mechanics Using Untethered Soft Robotic Microdevices.

作者信息

Parreira Raquel, Özelçi Ece, Sakar Mahmut Selman

机构信息

School of Engineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

出版信息

Front Robot AI. 2021 Mar 18;8:649765. doi: 10.3389/frobt.2021.649765. eCollection 2021.

DOI:10.3389/frobt.2021.649765
PMID:33869296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8044975/
Abstract

This paper presents the design, fabrication, and operation of a soft robotic compression device that is remotely powered by laser illumination. We combined the rapid and wireless response of hybrid nanomaterials with state-of-the-art microengineering techniques to develop machinery that can apply physiologically relevant mechanical loading. The passive hydrogel structures that constitute the compliant skeleton of the machines were fabricated using single-step polymerization process and directly incorporated around the actuators without further assembly steps. Experimentally validated computational models guided the design of the compression mechanism. We incorporated a cantilever beam to the prototype for life-time monitoring of mechanical properties of cell clusters on optical microscopes. The mechanical and biochemical compatibility of the chosen materials with living cells together with the on-site manufacturing process enable seamless interfacing of soft robotic devices with biological specimen.

摘要

本文介绍了一种由激光照射远程供电的软机器人压缩装置的设计、制造和操作。我们将混合纳米材料的快速无线响应与最先进的微工程技术相结合,开发出能够施加生理相关机械负荷的机械装置。构成机器柔顺骨架的无源水凝胶结构采用单步聚合工艺制造,并直接整合在致动器周围,无需进一步组装步骤。经过实验验证的计算模型指导了压缩机制的设计。我们在原型中加入了悬臂梁,用于在光学显微镜上对细胞簇的机械性能进行长期监测。所选材料与活细胞的机械和生化兼容性以及现场制造工艺,使得软机器人设备能够与生物样本无缝对接。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d42/8044975/5fd2b142916a/frobt-08-649765-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d42/8044975/57f1ad60d595/frobt-08-649765-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d42/8044975/4dda01ac6924/frobt-08-649765-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d42/8044975/d0a8f48b5c88/frobt-08-649765-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d42/8044975/7c6d1fa318d4/frobt-08-649765-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d42/8044975/5fd2b142916a/frobt-08-649765-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d42/8044975/57f1ad60d595/frobt-08-649765-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d42/8044975/4dda01ac6924/frobt-08-649765-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d42/8044975/d0a8f48b5c88/frobt-08-649765-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d42/8044975/7c6d1fa318d4/frobt-08-649765-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d42/8044975/5fd2b142916a/frobt-08-649765-g0005.jpg

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2
Addressable Acoustic Actuation of 3D Printed Soft Robotic Microsystems.3D打印软机器人微系统的可寻址声学驱动
Adv Sci (Weinh). 2020 Sep 21;7(20):2001120. doi: 10.1002/advs.202001120. eCollection 2020 Oct.
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