性别不匹配对心脏移植术后预后的影响。
Influence of Sex-Mismatch on Prognosis After Heart Transplantation.
作者信息
Ayesta Ana
机构信息
Heart Area, Hospital Universitario Central de Asturias, Oviedo, Spain.
出版信息
Front Cardiovasc Med. 2021 Mar 25;8:617062. doi: 10.3389/fcvm.2021.617062. eCollection 2021.
Abstract
The influence of donor and recipient sex on prognosis after heart transplantation has been analyzed in single, multi-center studies, and international registries. In most of them, sex-mismatch was identified as a risk factor for the worst prognosis, especially in men recipients of female heart. This could be attributed to physiological differences between women and men, differences in complications rates after heart transplantation (rejection, cardiovascular allograft vasculopathy, and primary graft failure), and pulmonary hypertension of the recipient. Confounding variables as age, urgent transplantation, and size-mismatch should also be considered. When allocating a graft, sex-mismatch should be considered but its influence in long-term survival should be further explored.
摘要
在单中心、多中心研究以及国际登记处中，已对供体和受体性别对心脏移植后预后的影响进行了分析。在大多数此类研究中，性别不匹配被确定为预后最差的一个风险因素，尤其是在接受女性心脏的男性受体中。这可能归因于男性和女性之间的生理差异、心脏移植后并发症发生率的差异（排斥反应、心血管移植物血管病变和原发性移植物功能衰竭）以及受体的肺动脉高压。年龄、紧急移植和大小不匹配等混杂变量也应予以考虑。在分配移植物时，应考虑性别不匹配，但对其对长期生存的影响仍需进一步探究。
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