Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aobaku, Sendai, 980-8575, Japan.
Department of Thoracic Surgery, The University of Tokyo, Tokyo, Japan.
Surg Today. 2023 Oct;53(10):1188-1198. doi: 10.1007/s00595-023-02686-w. Epub 2023 Apr 19.
To clarify the impact of donor and recipient characteristics on the survival of recipients before and after lung transplantation in the Japanese population.
Patients' data were collected for retrospective analysis from all authorized lung transplant centers in Japan. We included 1963 patients listed for lung transplantation by the end of December 2021, comprised of 658 deceased-donor and 270 living-donor lung transplants.
Primary disease had a significant impact on the mortality of patients waiting for transplantation. The indications for transplant significantly affected the post-transplant survival rate of deceased-donor lung transplant recipients. The recipient's age also significantly affected the post-transplant survival rate of the deceased-donor and living-donor lung transplant recipients. The recipients of grafts transplanted from donors aged 61 years or older showed a worse post-transplant survival rate (≧60 years old). The survival rate for the combination of a female donor to a male recipient among the deceased-donor lung transplant recipients was the worst among the four combinations.
The donor and recipient characteristics significantly impacted the survival of recipients after lung transplantation. The underlying mechanism of the negative impact of the gender mismatch of female donor to male recipient on post-transplant survival needs to be investigated further.
阐明在日本人群中，供体和受者特征对肺移植前后受者生存率的影响。
从日本所有授权的肺移植中心收集患者数据进行回顾性分析。我们纳入了截至 2021 年 12 月底登记的 1963 例肺移植患者，包括 658 例已故供体和 270 例活体供体肺移植。
原发疾病对移植等待患者的死亡率有显著影响。移植适应证显著影响已故供体肺移植受者的移植后生存率。受者年龄也显著影响已故供体和活体供体肺移植受者的移植后生存率。来自 61 岁或以上供体的移植物移植后受者的生存率较差（≧60 岁）。在已故供体肺移植受者中，女性供体与男性受者的组合的移植后生存率最差。
供体和受者特征显著影响肺移植后受者的生存率。需要进一步研究女性供体与男性受者性别不匹配对移植后生存的负面影响的潜在机制。
