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急性主动脉夹层中循环内皮祖细胞数量及活性降低及其与白细胞介素-6和白细胞介素-17的关系

Reduced Number and Activity of Circulating Endothelial Progenitor Cells in Acute Aortic Dissection and Its Relationship With IL-6 and IL-17.

作者信息

Huang Zhenhua, Liu Zhihao, Wang Keke, Ye Zi, Xiong Yan, Zhang Bin, Liao Jinli, Zeng Lijing, Zeng Haitao, Liu Gexiu, Zhan Hong, Yang Zhen

机构信息

Division of Emergency Medicine, Department of Emergency Intensive Care Unit, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Department of Cardiovascular Disease, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, China.

出版信息

Front Cardiovasc Med. 2021 Mar 29;8:628462. doi: 10.3389/fcvm.2021.628462. eCollection 2021.

DOI:10.3389/fcvm.2021.628462
PMID:33869300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8044799/
Abstract

This study investigates the alteration in function and number of circulating endothelial progenitor cells (EPCs) in patients with aortic dissection (AD), compared with hypertensive patients, and its possible mechanism. Thirty-four patients with acute aortic dissection (AAD) and 20 patients with primary hypertension were involved. Flow cytometry analysis was performed to detect the number of CD34+/KDR+ cells, and acetylated low density lipoprotein (ac-LDL) and lectin fluorescent staining method was applied to test the number of cultured EPCs. In addition, EPC migration and proliferation were measured, and plasma interleukin 6 (IL-6) and interleukin 17 (IL-17) levels were investigated. The number of circulating EPCs in the AAD group was lower than that in the non-AD group, and the proliferation and migration of circulating EPCs in the AAD group were lower than that in the non-AD group. In addition, the number, proliferation, and migration of circulating EPCs were significantly inversely correlated with the aortic dissection detection risk score (ADD-RS). More importantly, increased plasma IL-6 and IL-17 level was found in the AAD group, and the two inflammatory factors were inversely associated with the function and number of circulating EPCs in the AAD group. We first demonstrated that the number and function of circulating EPCs are reduced in the AAD group, which may be partly related to upregulated plasma IL-6 and IL-17. Our study provides novel insight on the underlying mechanism and potential therapeutic target of AAD.

摘要

本研究调查了主动脉夹层（AD）患者与高血压患者相比，循环内皮祖细胞（EPCs）功能和数量的变化及其可能机制。纳入了34例急性主动脉夹层（AAD）患者和20例原发性高血压患者。采用流式细胞术分析检测CD34+/KDR+细胞数量，应用乙酰化低密度脂蛋白（ac-LDL）和凝集素荧光染色法检测培养的EPCs数量。此外，检测了EPCs的迁移和增殖情况，并研究了血浆白细胞介素6（IL-6）和白细胞介素17（IL-17）水平。AAD组循环EPCs数量低于非AD组，AAD组循环EPCs的增殖和迁移能力低于非AD组。此外，循环EPCs的数量、增殖和迁移与主动脉夹层检测风险评分（ADD-RS）显著负相关。更重要的是，发现AAD组血浆IL-6和IL-17水平升高，这两种炎症因子与AAD组循环EPCs的功能和数量呈负相关。我们首次证明AAD组循环EPCs的数量和功能降低，这可能部分与血浆IL-6和IL-17上调有关。我们的研究为AAD的潜在机制和潜在治疗靶点提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/ac1b245f6490/fcvm-08-628462-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/8e010c8456f9/fcvm-08-628462-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/eb557c3d2764/fcvm-08-628462-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/70fde2612a4a/fcvm-08-628462-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/e601fc6852a3/fcvm-08-628462-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/e7a75290d8e8/fcvm-08-628462-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/ac1b245f6490/fcvm-08-628462-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/8e010c8456f9/fcvm-08-628462-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/eb557c3d2764/fcvm-08-628462-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/70fde2612a4a/fcvm-08-628462-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/e601fc6852a3/fcvm-08-628462-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/e7a75290d8e8/fcvm-08-628462-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/8044799/ac1b245f6490/fcvm-08-628462-g0006.jpg

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