Shi Henglei, Zhao Zhenchen, Jiang Weidong, Zhu Peiqi, Zhou Nuo, Huang Xuanping
Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guangxi Medical University, Nanning, China.
Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Disease Treatment, Guangxi Clinical Research Center for Craniofacia Reconstruction, Guangxi Key Laboratory of Oral and Maxillofacial Surg Deformity, Nanning, China.
Front Cell Dev Biol. 2022 May 24;10:878697. doi: 10.3389/fcell.2022.878697. eCollection 2022.
In addition to its important transport functions, the skeletal system is involved in complex biological activities for the regulation of blood vessels. Endothelial progenitor cells (EPCs), as stem cells of endothelial cells (ECs), possess an effective proliferative capacity and a powerful angiogenic capacity prior to their differentiation. They demonstrate synergistic effects to promote bone regeneration and vascularization more effectively by co-culturing with multiple cells. EPCs demonstrate a significant therapeutic potential for the treatment of various bone diseases by secreting a combination of growth factors, regulating cellular functions, and promoting bone regeneration. In this review, we retrospect the definition and properties of EPCs, their interaction with mesenchymal stem cells, ECs, smooth muscle cells, and immune cells in bone regeneration, vascularization, and immunity, summarizing their mechanism of action and contribution to bone biology. Additionally, we generalized their role and potential mechanisms in the treatment of various bone diseases, possibly indicating their clinical application.
除了其重要的运输功能外，骨骼系统还参与调节血管的复杂生物活动。内皮祖细胞（EPCs）作为内皮细胞（ECs）的干细胞，在分化之前具有有效的增殖能力和强大的血管生成能力。它们通过与多种细胞共培养表现出协同作用，更有效地促进骨再生和血管生成。EPCs通过分泌多种生长因子、调节细胞功能和促进骨再生，在治疗各种骨疾病方面显示出巨大的治疗潜力。在这篇综述中，我们回顾了EPCs的定义和特性，它们在骨再生、血管生成和免疫中与间充质干细胞、内皮细胞、平滑肌细胞和免疫细胞的相互作用，总结了它们的作用机制以及对骨生物学的贡献。此外，我们概括了它们在治疗各种骨疾病中的作用和潜在机制，这可能预示着它们的临床应用。
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