Chen Lisha, Li Mengying, Xu Ting, Qiu Xiufang, Chen Chuanben
Department of Radiation Oncology Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fujian Medical University Fuzhou Fujian Province China.
Laryngoscope Investig Otolaryngol. 2021 Mar 11;6(2):219-225. doi: 10.1002/lio2.548. eCollection 2021 Apr.
To investigate the relationship between absolute neutrophils count (ANC) in different periods of treatment and the outcomes of patients and assess effect of longitudinal neutrophils variation during radiotherapy (RT) on prognosis in patients with nasopharyngeal carcinoma (NPC).
A total of 1753 patients with newly diagnosed NPC were retrospectively analyzed. Complete blood counts of patients were obtained before treatment, before, during, and end of RT. The survival rate was calculated by Kaplan-Meier method and the result was compared by the log-rank test. The univariate and multivariate COX regression analyses were performed to investigate the association between the variation of ANC and survival for patients in different periods.
Higher ANC pretreatment (>4 × 10/L) and pre-RT (>7 × 10/L) were correlated with poor OS (89.7% vs 85.6%, = .009; 88.3% vs 77.3%, = .002, respectively). An increase >5 × 10/L of ANC during RT was associated with adverse OS (87.9% vs 73.6%, = .042). The multivariate Cox regression analysis showed that high ANC of pre-RT (>7 × 10/L) and a high increase (>5 × 10/L) of ANC during RT were independent prognostic factors of patients with NPC ( = .002, .044, respectively).
Our results demonstrated that ANC was an independent prognostic factor for survival in patients with NPC who received RT. Neutrophils may promote tumor resistance to radiotherapy in NPC.
2a.
探讨鼻咽癌（NPC）患者治疗不同阶段的绝对中性粒细胞计数（ANC）与患者预后的关系，并评估放疗（RT）期间中性粒细胞纵向变化对患者预后的影响。
回顾性分析1753例新诊断的NPC患者。在治疗前、放疗前、放疗期间及放疗结束时获取患者的全血细胞计数。采用Kaplan-Meier法计算生存率，并通过对数秩检验比较结果。进行单因素和多因素COX回归分析，以研究不同时期ANC变化与患者生存的相关性。
治疗前ANC较高（>4×10⁹/L）和放疗前ANC较高（>7×10⁹/L）与总生存期较差相关（分别为89.7%对85.6%，P = 0.009；88.3%对77.3%，P = 0.002）。放疗期间ANC升高>5×10⁹/L与不良总生存期相关（87.9%对73.6%，P = 0.042）。多因素Cox回归分析显示，放疗前ANC高（>7×10⁹/L）和放疗期间ANC升高幅度大（>5×10⁹/L）是NPC患者的独立预后因素（分别为P = 0.002，P = 0.044）。
我们的结果表明，ANC是接受放疗的NPC患者生存的独立预后因素。中性粒细胞可能促进NPC对放疗的抵抗。
2a。
