McCullough Shaun D, Dhingra Radhika, Fortin Marie C, Diaz-Sanchez David
National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711.
Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08855.
Curr Opin Toxicol. 2017 Oct 1;6:18-25. doi: 10.1016/j.cotox.2017.07.001.
The field of toxicoepigenetics is rapidly emerging to provide new insights into the relationship between environmental factors, the epigenome, and public health. Toxicoepigenetic data have the potential to revolutionize our understanding of environmental exposure effects and susceptibility. Studies in recent years have demonstrated that exposure to air pollution alters epigenetic modification states; however, continued advancement of the field is limited by the intrinsic complexity of the epigenome and inherent limitations of different types of studies (epidemiological, clinical, and ) that are used in toxicoepigenetics. Overcoming these challenges will require a concerted and collaborative effort between molecular and cellular biologists, toxicologists, epidemiologists, and risk assessors to develop a thorough and practical understanding of the relationship between air pollution exposure, the epigenome, and health effects. Here we review the current state of air pollution epigenetics and discuss perspectives on the necessary steps to move the field forward to determine the role that the epigenome plays in air pollution exposure effects and susceptibility.
毒理表观遗传学领域正在迅速兴起，为深入了解环境因素、表观基因组与公众健康之间的关系提供新的视角。毒理表观遗传学数据有可能彻底改变我们对环境暴露影响和易感性的理解。近年来的研究表明，接触空气污染会改变表观遗传修饰状态；然而，该领域的持续发展受到表观基因组内在复杂性以及毒理表观遗传学中使用的不同类型研究（流行病学、临床等）固有局限性的限制。克服这些挑战需要分子和细胞生物学家、毒理学家、流行病学家和风险评估师共同协作，以全面、实际地理解空气污染暴露、表观基因组与健康影响之间的关系。在此，我们综述空气污染表观遗传学的现状，并讨论推动该领域向前发展所需采取的必要步骤，以确定表观基因组在空气污染暴露影响和易感性中所起的作用。
