Takamura Yusaku, Fujii Shintaro, Ohmatsu Satoko, Morioka Shu, Kawashima Noritaka
Department of Rehabilitation for the Movement Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama, Japan.
Graduate School of Health Science, Kio University, Nara, Japan.
iScience. 2021 Mar 16;24(4):102316. doi: 10.1016/j.isci.2021.102316. eCollection 2021 Apr 23.
Visuospatial neglect (VSN) is a neurological syndrome of higher brain functions in which an individual fails to detect stimuli on a space that is contralateral to a hemispheric lesion. We performed a comprehensive multivariate analysis based on the principal component analysis (PCA) and cluster analysis in patients with right hemisphere stroke and then performed a determination of different elements of VSN. PCA-based cluster analysis detected distinct aspects of VSN as follows: cluster 1: low arousal and attention state, cluster 2: exogenous neglect, cluster 3: spatial working memory (SWM) deficit. Lesion analysis revealed neural correlates for each cluster and highlighted "disturbance of the ventral attention network" for the stagnation of exogenous attention and "parietal damage" for SWM deficit. Our results reveal a pathological structure of VSN as multiple components of an attention network deficit, and they contribute to the understanding of the mechanisms underlying VSN.
视觉空间忽视（VSN）是一种高级脑功能的神经综合征，患者无法检测到与半球病变对侧空间的刺激。我们对右半球中风患者进行了基于主成分分析（PCA）和聚类分析的综合多变量分析，然后确定了VSN的不同要素。基于PCA的聚类分析检测到VSN的不同方面如下：聚类1：低觉醒和注意力状态，聚类2：外源性忽视，聚类3：空间工作记忆（SWM）缺陷。病变分析揭示了每个聚类的神经相关性，并突出了外源性注意力停滞的“腹侧注意力网络障碍”和SWM缺陷的“顶叶损伤”。我们的结果揭示了VSN作为注意力网络缺陷的多个组成部分的病理结构，有助于理解VSN的潜在机制。
