Zhou Rongyi, Xie Xinyue, Wang Jiaojiao, Ma Bingxiang, Hao Xin
Department of Pediatrics, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Henan Provincial People's Hospital, Henan Institute of Ophthalmology, Zhengzhou, China.
Front Psychiatry. 2023 May 15;14:1087122. doi: 10.3389/fpsyt.2023.1087122. eCollection 2023.
Autism spectrum disorder (ASD) is associated with severe impairment in social functioning. Visual information processing provides nonverbal cues that support social interactions. ASD children exhibit abnormalities in visual orientation, continuous visual exploration, and visual-spatial perception, causing social dysfunction, and mechanisms underlying these abnormalities remain unclear. Transmission of visual information depends on the retina-lateral geniculate nucleus-visual cortex pathway. In ASD, developmental abnormalities occur in rapid expansion of the visual cortex surface area with constant thickness during early life, causing abnormal transmission of the peak of the visual evoked potential (P100). We hypothesized that abnormal visual perception in ASD are related to the abnormal visual information transmission and abnormal development of visual cortex in early life, what's more, explored the mechanisms of abnormal visual symptoms to provide suggestions for future research.
自闭症谱系障碍(ASD)与社交功能的严重受损有关。视觉信息处理提供支持社交互动的非语言线索。ASD儿童在视觉定向、持续视觉探索和视觉空间感知方面表现出异常,导致社交功能障碍,而这些异常背后的机制仍不清楚。视觉信息的传递依赖于视网膜-外侧膝状体-视觉皮层通路。在ASD中,在生命早期视觉皮层表面积以恒定厚度快速扩张时会出现发育异常,导致视觉诱发电位(P100)峰值的异常传递。我们假设ASD中异常的视觉感知与早期生命中异常的视觉信息传递和视觉皮层的异常发育有关,此外,还探讨了异常视觉症状的机制,为未来的研究提供建议。