Scaplen Kristin M, Petruccelli Emily
Department of Psychology, Bryant University, Smithfield, RI, USA.
Center for Health and Behavioral Studies, Bryant University, Smithfield, RI, USA.
Neurosci Insights. 2021 Mar 30;16:26331055211007441. doi: 10.1177/26331055211007441. eCollection 2021.
Alcohol Use Disorder (AUD) is a debilitating disorder that manifests as problematic patterns of alcohol use. At the core of AUD's behavioral manifestations are the profound structural, physiological, cellular, and molecular effects of alcohol on the brain. While the field has made considerable progress in understanding the neuromolecular targets of alcohol we still lack a comprehensive understanding of alcohol's actions and effective treatment strategies. is a powerful model for investigating the neuromolecular targets of alcohol because flies model many of the core behavioral elements of AUD and offer a rich genetic toolkit to precisely reveal the in vivo molecular actions of alcohol. In this review, we focus on receptors and channels that are often targeted by alcohol within the brain. We discuss the general roles of these proteins, their role in alcohol-associated behaviors across species, and propose ways in which models can help advance the field.
酒精使用障碍（AUD）是一种使人衰弱的疾病，表现为饮酒的问题模式。AUD行为表现的核心是酒精对大脑产生的深刻的结构、生理、细胞和分子影响。虽然该领域在理解酒精的神经分子靶点方面取得了相当大的进展，但我们仍然缺乏对酒精作用和有效治疗策略的全面理解。果蝇是研究酒精神经分子靶点的有力模型，因为果蝇模拟了AUD的许多核心行为要素，并提供了丰富的遗传工具包来精确揭示酒精在体内的分子作用。在这篇综述中，我们重点关注大脑中经常被酒精靶向的受体和通道。我们讨论了这些蛋白质的一般作用、它们在跨物种酒精相关行为中的作用，并提出了果蝇模型有助于推动该领域发展的方式。
