从醉酒的果蝇中得到的启示。
Insights from intoxicated Drosophila.
机构信息
Neuroscience Department, Brown University, Providence, RI 02912, United States.
Neuroscience Department, Brown University, Providence, RI 02912, United States.
出版信息
Alcohol. 2019 Feb;74:21-27. doi: 10.1016/j.alcohol.2018.03.004. Epub 2018 Mar 21.
Abstract
Our understanding of alcohol use disorder (AUD), particularly alcohol's effects on the nervous system, has unquestionably benefited from the use of model systems such as Drosophila melanogaster. Here, we briefly introduce the use of flies in alcohol research, and highlight the genetic accessibility and neurobiological contribution that flies have made to our understanding of AUD. Future fly research offers unique opportunities for addressing unresolved questions in the alcohol field, such as the neuromolecular and circuit basis for cravings and alcohol-induced neuroimmune dysfunction. This review strongly advocates for interdisciplinary approaches and translational collaborations with the united goal of confronting the major health problems associated with alcohol abuse and addiction.
摘要
我们对酒精使用障碍（AUD）的理解，特别是酒精对神经系统的影响，无疑受益于使用模型系统，如黑腹果蝇。在这里，我们简要介绍了在酒精研究中使用果蝇，并强调了果蝇在我们对 AUD 的理解方面所做出的遗传可及性和神经生物学贡献。未来的果蝇研究为解决酒精领域尚未解决的问题提供了独特的机会，例如对渴望和酒精引起的神经免疫功能障碍的神经分子和电路基础的研究。这篇综述强烈主张采取跨学科的方法和转化合作，以共同应对与滥用和成瘾性酒精相关的主要健康问题。
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2
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3
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6
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