Department of Otorhinolaryngology, Hendek State Hospital, Çağlayan Mahallesi Dr. Cevdet Şahinli Caddesi No:30, 54300, Hendek/Sakarya, Turkey.
Department of Otorhinolaryngology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
Eur Arch Otorhinolaryngol. 2022 Mar;279(3):1311-1316. doi: 10.1007/s00405-021-06804-7. Epub 2021 Apr 18.
The aim of this study was to investigate the importance of atherosclerosis in the pathogenesis of sudden hearing loss by evaluating the newly discovered markers, serum salusin-α and salusin-β. We also aimed to evaluate atherosclerosis risk factors, such as lipid profile, smoking, body mass index, waist circumference and mean blood pressure of the patients.
Fifty-two patients diagnosed with sudden hearing loss (study group) and fifty healthy people (control group) were included in the study. Detailed history was taken from the patients and risk factors for atherosclerosis, such as smoking, body mass index, waist circumference, lipid profile, mean blood pressure and serum salusin-α and salusin-β levels, were evaluated. The study group was divided into recovery group (subgroup I) and non-recovery group (subgroup II).
The salusin-β median value was found to be significantly higher in the study group compared to the control group (p < 0.05). The salusin-β median value was found to be significantly higher in subgroup 2 and was found to be a poor prognostic factor (p < 0.05).
From the results obtained in this study, it is thought that salusin-β peptide is increased in patients with sudden hearing loss and it can be evaluated as a poor prognostic factor.
本研究旨在通过评估新发现的标志物血清salusin-α和salusin-β，探讨动脉粥样硬化在突发性听力损失发病机制中的重要性。我们还旨在评估患者的动脉粥样硬化危险因素，如血脂谱、吸烟、体重指数、腰围和平均血压。
本研究纳入了 52 名诊断为突发性听力损失的患者（研究组）和 50 名健康人（对照组）。从患者那里获取详细病史，并评估动脉粥样硬化的危险因素，如吸烟、体重指数、腰围、血脂谱、平均血压以及血清 salusin-α 和 salusin-β 水平。研究组分为恢复组（亚组 I）和未恢复组（亚组 II）。
研究组的 salusin-β 中位数明显高于对照组（p<0.05）。亚组 2 的 salusin-β 中位数明显较高，且为预后不良的因素（p<0.05）。
从本研究结果来看，salusin-β 肽在突发性听力损失患者中增加，可作为预后不良的因素进行评估。
