用于抗菌应用的低维纳米材料。

Low-dimensional nanomaterials for antibacterial applications.

机构信息

Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Frontiers Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, China.

Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

出版信息

J Mater Chem B. 2021 May 5;9(17):3640-3661. doi: 10.1039/d1tb00033k.

DOI:10.1039/d1tb00033k

PMID:33870985

Abstract

The excessive use of antibiotics has led to a rise in drug-resistant bacteria. These "superbugs" are continuously emerging and becoming increasingly harder to treat. As a result, new and effective treatment protocols that have minimal risks of generating drug-resistant bacteria are urgently required. Advanced nanomaterials are particularly promising due to their drug loading/releasing capabilities combined with their potential photodynamic/photothermal therapeutic properties. In this review, 0-dimensional, 1-dimensional, 2-dimensional, and 3-dimensional nanomaterial-based systems are comprehensively discussed for bacterial-based diagnostic and treatment applications. Since the use of these platforms as antibacterials is relatively new, this review will provide appropriate insight into their construction and applications. As such, we hope this review will inspire researchers to explore antibacterial-based nanomaterials with the aim of developing systems for clinical applications.

摘要

抗生素的过度使用导致了耐药菌的增加。这些“超级细菌”不断出现，且越来越难以治疗。因此，迫切需要新的、有效的治疗方案，这些方案的风险要最小化，且生成耐药菌的风险要最小化。先进的纳米材料由于其载药/释药能力以及潜在的光动力/光热治疗特性而具有很大的应用前景。在这篇综述中，我们全面讨论了基于 0 维、1 维、2 维和 3 维纳米材料的系统，用于细菌的诊断和治疗应用。由于这些平台作为抗菌剂的使用相对较新，因此本综述将提供有关其构建和应用的适当见解。因此，我们希望本综述能够激发研究人员探索基于纳米材料的抗菌剂，以期开发用于临床应用的系统。