基于刚性的圆柱状聚合物刷的胞内位置分布。
Stiffness-Dependent Intracellular Location of Cylindrical Polymer Brushes.
机构信息
Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.
The University of Sydney Nano Institute (Sydney Nano), The University of Sydney, Sydney, NSW, 2006, Australia.
出版信息
Macromol Rapid Commun. 2021 Jul;42(13):e2100138. doi: 10.1002/marc.202100138. Epub 2021 Apr 19.
Cylindrical polymer brushes (CPBs) are macromolecules with nanoparticle proportions. Their modular synthesis enables tailoring of their chemical composition as well as the dialing-up of overall dimensions and physicochemical properties. In this study, two rod-like poly[(ethylene glycol) methyl ether methacrylate] (PEGMA)-based CPBs with varying stiffness but otherwise comparable features and functionality, are synthesized. Differences in particle stiffness are assessed using small angle neutron scattering (SANS). It is observed that the fate of the two CPBs within cells is distinctly different. Stiffer CPBs seem to gravitate toward the mitochondria, whereas CPBs with reduced stiffness are present in different intracellular vesicles.
圆柱形聚合物刷（CPBs）是具有纳米颗粒比例的高分子。它们的模块化合成能够调整其化学成分，以及整体尺寸和物理化学性质。在这项研究中，合成了两种具有不同刚性但具有可比特征和功能的棒状聚（乙二醇）甲基醚甲基丙烯酸酯（PEGMA）基 CPB。使用小角中子散射（SANS）评估颗粒刚性的差异。观察到两种 CPB 在细胞内的命运明显不同。刚性较大的 CPB 似乎趋向于线粒体，而刚性降低的 CPB 则存在于不同的细胞内囊泡中。
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