Department of Chemistry, The University of Warwick, Coventry CV4 7AL, U.K.
Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, VIC, Australia.
Biomacromolecules. 2022 Jun 13;23(6):2315-2328. doi: 10.1021/acs.biomac.2c00063. Epub 2022 May 18.
Rod-shaped nanoparticles have been identified as promising drug delivery candidates. In this report, the in vitro cell uptake and in vivo pharmacokinetic/bio-distribution behavior of molecular bottle-brush (BB) and cyclic peptide self-assembled nanotubes were studied in the size range of 36-41 nm in length. It was found that BB possessed the longest plasma circulation time ( > 35 h), with the cyclic peptide system displaying an intermediate half-life (14.6 h), although still substantially elevated over a non-assembling linear control (2.7 h). The covalently bound BB underwent substantial distribution into the liver, whereas the cyclic peptide nanotube was able to mostly circumvent organ accumulation, highlighting the advantage of the inherent degradability of the cyclic peptide systems through their reversible aggregation of hydrogen bonding core units.
棒状纳米颗粒已被鉴定为有前途的药物输送候选物。在本报告中，研究了分子刷（BB）和环状肽自组装纳米管在 36-41nm 长度范围内的体外细胞摄取和体内药代动力学/生物分布行为。结果发现，BB 具有最长的血浆循环时间（>35h），而环状肽系统显示出中等半衰期（14.6h），尽管仍远高于非组装线性对照（2.7h）。共价结合的 BB 大量分布到肝脏中，而环状肽纳米管则能够主要避免器官积累，这突出了环状肽系统通过其氢键核心单元的可逆聚集而具有内在可降解性的优势。
