State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, China.
College of Biology, Hunan University, Changsha, P. R. China.
Chem Commun (Camb). 2021 Apr 25;57(32):3873-3876. doi: 10.1039/d1cc00818h. Epub 2021 Mar 22.
Endogenous miRNA expression patterns are extremely cell-type-specific, thereby offering high prediction accuracy for different cell identities. Here, a DNA-tetrahedron-based "AND" logic gate is utilized as a molecular device that recognizes dual-miRNA inputs through strand hybridization to activate a computation cascade that produces controlled singlet oxygen in live cells, resulting in the death of the target cell.
内源性 miRNA 表达模式具有极强的细胞类型特异性，因此能够对不同的细胞身份进行高精度预测。在这里，一种基于 DNA 四面体的“与”逻辑门被用作分子器件，通过链杂交识别双 miRNA 输入，激活计算级联反应，在活细胞中产生受控的单线态氧，从而导致靶细胞死亡。
