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Intelligent layered nanoflare: "lab-on-a-nanoparticle" for multiple DNA logic gate operations and efficient intracellular delivery.智能分层纳荧光:“纳米颗粒上的实验室”用于多种 DNA 逻辑门操作和高效的细胞内递药。
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分而治之:多输入DNA逻辑门的拆分设计

Divide and control: split design of multi-input DNA logic gates.

作者信息

Gerasimova Yulia V, Kolpashchikov Dmitry M

机构信息

Chemistry Department, University of Central Florida, Orlando, FL 32816, USA.

出版信息

Chem Commun (Camb). 2015 Jan 18;51(5):870-2. doi: 10.1039/c4cc08241a. Epub 2014 Nov 27.

DOI:10.1039/c4cc08241a
PMID:25513764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4494086/
Abstract

Logic gates made of DNA have received significant attention as biocompatible building blocks for molecular circuits. The majority of DNA logic gates, however, are controlled by the minimum number of inputs: one, two or three. Here we report a strategy to design a multi-input logic gate by splitting a DNA construct.

摘要

由DNA制成的逻辑门作为分子电路的生物相容性构建模块受到了广泛关注。然而,大多数DNA逻辑门由最少数量的输入控制:一个、两个或三个。在此,我们报告了一种通过拆分DNA构建体来设计多输入逻辑门的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c87/4494086/a9aa77aa275d/nihms704049f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c87/4494086/f13bb1e192af/nihms704049f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c87/4494086/a9aa77aa275d/nihms704049f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c87/4494086/f13bb1e192af/nihms704049f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c87/4494086/a9aa77aa275d/nihms704049f2.jpg