与磁共振成像中静脉造影剂使用相关的安全性问题。
Safety issues related to intravenous contrast agent use in magnetic resonance imaging.
机构信息
Department of Radiology, Children's Hospital Los Angeles, 4650 Sunset Blvd., MS# 81, Los Angeles, CA, 90064, USA.
Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
出版信息
Pediatr Radiol. 2021 May;51(5):736-747. doi: 10.1007/s00247-020-04896-7. Epub 2021 Apr 19.
Gadolinium-based contrast agents (GBCAs) have been used to improve image quality of MRI examinations for decades and have an excellent overall safety record. However, there are well-documented risks associated with GBCAs and our understanding and management of these risks continue to evolve. The purpose of this review is to discuss the safety of GBCAs used in MRI in adult and pediatric populations. We focus particular attention on acute adverse reactions, nephrogenic systemic fibrosis and gadolinium deposition. We also discuss the non-GBCA MRI contrast agent ferumoxytol, which is increasing in use and has its own risk profile. Finally, we identify special populations at higher risk of harm from GBCA administration.
钆基造影剂（GBCA）已被用于提高磁共振成像（MRI）检查的图像质量数十年，其具有良好的整体安全性记录。然而，GBCA 与一些已被充分记录的风险相关，并且我们对这些风险的理解和管理仍在不断发展。本综述的目的是讨论 MRI 中在成人和儿科人群中使用 GBCA 的安全性。我们特别关注急性不良反应、肾源性系统纤维化和钆沉积。我们还讨论了非 GBCA 的 MRI 造影剂铁氧体，其应用日益增多，并有其自身的风险特征。最后，我们确定了 GBCA 给药风险较高的特殊人群。
Zotero 插件