术前血小板-淋巴细胞比值可预测喉鳞状细胞癌的复发。
Preoperative platelet-lymphocyte ratio predicts recurrence of laryngeal squamous cell carcinoma.
机构信息
Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029, PR China.
出版信息
Future Oncol. 2020 Feb;16(6):209-217. doi: 10.2217/fon-2019-0527. Epub 2020 Jan 27.
To evaluate the impact of preoperative platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), derived NLR (dNLR) and lymphocyte-monocyte ratio (LMR) on the prognosis of laryngeal squamous cell carcinoma. Overall survival and recurrence-free survival (RFS) were analyzed using Kaplan-Meier estimates. Multivariable Cox regression model was used to evaluate the independent prognostic significance of variables. High PLR (>103.96), NLR (>1.96) and dNLR (>1.70) predicted lower RFS according to Kaplan-Meier method. In COX regression model, patients with high PLR had poor RFS estimates compared with those with lower PLR (p < 0.001). Preoperative PLR was a more valuable prognostic factor than NLR, dNLR and LMR for the recurrence of laryngeal squamous cell carcinoma.
为了评估术前血小板-淋巴细胞比值（PLR）、中性粒细胞-淋巴细胞比值（NLR）、衍生 NLR（dNLR）和淋巴细胞-单核细胞比值（LMR）对喉鳞状细胞癌预后的影响。采用 Kaplan-Meier 估计法分析总生存率和无复发生存率（RFS）。采用多变量 Cox 回归模型评估变量的独立预后意义。根据 Kaplan-Meier 法，高 PLR（>103.96）、NLR（>1.96）和 dNLR（>1.70）预测 RFS 较低。在 COX 回归模型中，与低 PLR 患者相比，高 PLR 患者的 RFS 估计值较差（p<0.001）。术前 PLR 是预测喉鳞状细胞癌复发的比 NLR、dNLR 和 LMR 更有价值的预后因素。
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