Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Radiology, Faculty of Medicine, Cairo University, Cairo, Egypt.
J Psychiatr Res. 2021 Jun;138:272-279. doi: 10.1016/j.jpsychires.2021.04.010. Epub 2021 Apr 12.
The aim of this study was to assess the structural alteration of corpus callosum (CC) in adolescent females with Borderline Personality Disorder (BPD) and detect the relationship between these changes and BPD symptoms.
A comparative case control study was conducted on 50 adolescent females that were divided into 2 groups; 25 outpatients suffering from BPD (according to DSM-IV-TR diagnostic criteria) compared to 25 healthy adolescents. All subjects were assessed by Borderline Personality Questionnaire, Barratt impulsivity scale-11, Brief Non-Suicidal Self-Injury Assessment tool, Beck Scale for Suicidal Ideation, and Diffusion tensor imaging.
Relative to control subjects, BPD patients had significantly lower fractional anisotropy (FA) values in the genu and lower mean diffusivity (MD) values in the body of CC. There was a negative correlation between FA values in the genu and body of CC and impulsivity. MD in the body of CC was positively correlated with motor impulsiveness and negatively correlated with suicidality.
Adolescent females with BPD show structural alterations in the CC that are related to symptoms of emotional dysregulation and impulsivity.
本研究旨在评估边缘型人格障碍（BPD）青少年女性胼胝体（CC）的结构改变，并检测这些变化与 BPD 症状之间的关系。
对 50 名患有 BPD 的青少年女性（根据 DSM-IV-TR 诊断标准）和 25 名健康青少年进行了一项病例对照研究。所有受试者均接受了边缘性人格问卷、巴瑞特冲动量表-11、简短非自杀性自我伤害评估工具、贝克自杀意念量表和弥散张量成像评估。
与对照组相比，BPD 患者的 CC 体部和膝部的各向异性分数（FA）值显著降低，MD 值升高。CC 体部和膝部的 FA 值与冲动性呈负相关。CC 体部的 MD 值与运动冲动性呈正相关，与自杀意念呈负相关。
患有 BPD 的青少年女性表现出 CC 的结构改变，这些改变与情绪调节和冲动性症状有关。
